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PROW: CD66a
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD66a
Authors: Keith Skubitz; Fritz Grunert; Peter Jantscheff; Motomu Kuroki; Amy Skubitz
Reviewer:
Diverse coauthors in lieu of reviewer
Link to additional info in FORUM
[GUIDE BAR]

ALTERNATE NAMES FOR CD66a  

MAJOR LINKS FOR CD66a  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD66a   - Unclear, see ligands

CELLULAR FUNCTION OF CD66a  

DISEASE RELEVANCE OF CD66a AND FUNCTION OF CD66a IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD66a  

MOLECULAR STRUCTURE OF CD66a  

MOLECULAR MASS OF CD66a  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Various cells   140-180 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD66a  

POST-TRANSLATIONAL MODIFICATION OF CD66a  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD66a  
MOLECULECOMMENT
Upstream stimulatory factor (USF)  
Hepatic nuclear factor 4 (HNF-4)  
AP-2 like factor  

SUBSTRATES FOR CD66a   - No information

ENZYMES WHICH MODIFY CD66a  

MOLECULECOMMENT
src Phosphorylates cytoplasmic domain of CD66a

LIGANDS FOR CD66a AND MOLECULES ASSOCIATED WITH CD66a Link to additional info in FORUM  

MOLECULECOMMENT
CD62 E (E-selectin) CD66a carbohydrate groups interact with CD62 E (E-selectin)
Unknown molecule on bacteria Carbohydrate groups interact with bacteria
CD66a Binds the protein core of CD66a not the carbohydrate
CD66c Binds the protein core of CD66a not the carbohydrate
CD66e Binds the protein core of CD66a not the carbohydrate
src family kinases Some src family kinases associate with CD66a neutrophils

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD66a  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD66a  
REAGENTS
CD66a-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP   - See reference mAb

SELECTION OF OTHER CD66a-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
4.3.17 Fritz Grunert CD66ae mAbs
12-140-4 Ole Bormer, Oslo, Norway CD66ae mAbs

 
SELECTED REFERENCES ON CD66a  

REVIEWS

Virji M,Watt SM,Barker S,Makepeace K,Doyonnas R The N-domain of the human CD66a adhesion molecule is a target for Opa proteins of Neisseria meningitidis and Neisseria gonorrhoeae. Mol Microbiol 1996 22:929 PubMed

PRIMARY CITATIONS

1. Svenberg T,Hammarstrom S,Zeromski J Immunofluorescence studies on the occurrence and localization of the CEA-related biliary glycoprotein I (BGP I) in normal human gastrointestinal tissues. Clin Exp Immunol 1979 36:436 PubMed

2. Audette M,Buchegger F,Schreyer M,Mach JP Monoclonal antibody against carcinoembryonic antigen (CEA) identifies two new forms of crossreacting antigens of molecular weight 90,000 and 160,000 in normal granulocytes. Mol Immunol 1987 24:1177 PubMed

3. Thompson JA,Grunert F,Zimmermann W Carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J Clin Lab Anal 1991 5:344 PubMed

4. Barnett TR,Kretschmer A,Austen DA,Goebel SJ,Hart JT,Elting JJ,Kamarck ME Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family. J Cell Biol 1989 108:267 PubMed

5. Rojas M,Fuks A,Stanners CP Biliary glycoprotein, a member of the immunoglobulin supergene family, functions in vitro as a Ca2(+)-dependent intercellular adhesion molecule. Cell Growth Differ 1990 1:527 PubMed

6. Hauck W,Nedellec P,Turbide C,Stanners CP,Barnett TR,Beauchemin N Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas. Eur J Biochem 1994 223:529 PubMed

7. Neumaier M,Paululat S,Chan A,Matthaes P,Wagener C Biliary glycoprotein, a potential human cell adhesion molecule, is down- regulated in colorectal carcinomas. Proc Natl Acad Sci U S A 1993 90:10744 PubMed

8. Stocks SC,Kerr MA Stimulation of neutrophil adhesion by antibodies recognizing CD15 (Le(X)) and CD15-expressing carcinoembryonic antigen-related glycoprotein NCA-160. Biochem J 1992 288:23 PubMed

9. Skubitz KM,Campbell KD,Ahmed K,Skubitz AP CD66 family members are associated with tyrosine kinase activity in human neutrophils. J Immunol 1995 155:5382 PubMed

10. Skubitz KM,Campbell KD,Skubitz AP CD66a, CD66b, CD66c, and CD66d each independently stimulate neutrophils. J Leukoc Biol 1996 60:106 PubMed

11. Kuijpers TW,Hoogerwerf M,van der Laan LJ,Nagel G,van der Schoot CE,Grunert F,Roos D CD66 nonspecific cross-reacting antigens are involved in neutrophil adherence to cytokine-activated endothelial cells. J Cell Biol 1992 118:457 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

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Modified 10/14/99   mpr@mail.nih.gov