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PROW: CD69
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PROW and IWHLDA present the GUIDE on:
CD69
Author: Alessandro Poggi
Reviewer: Francisco Sanchez-Madrid
Link to additional info in FORUM
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ALTERNATE NAMES FOR CD69  

MAJOR LINKS FOR CD69  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD69   - No information

CELLULAR FUNCTION OF CD69 Link to additional info in FORUM  

DISEASE RELEVANCE OF CD69 AND FUNCTION OF CD69 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD69  

MOLECULAR STRUCTURE OF CD69  

MOLECULAR MASS OF CD69  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
NK cells 60 kDa 28/32 kDa  
Activated T lymphocytes** 60 kDa 27/33 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD69  

POST-TRANSLATIONAL MODIFICATION OF CD69  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD69  
MOLECULECOMMENT
NFkB Consensus sequence in promoter and NFkB regulates TNF alpha-mediated induction of CD69 gene expression**
AP-1 Consensus sequence in promoter **
NFAT Consensus sequence in promoter**
NFkB Consensus sequence in promoter**

SUBSTRATES FOR CD69   - No information

ENZYMES WHICH MODIFY CD69   - No information

LIGANDS FOR CD69 AND MOLECULES ASSOCIATED WITH CD69   - Unknown


EXPRESSION
MAIN CELLULAR EXPRESSION OF CD69  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD69  
REAGENTS
CD69-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP   - None

SELECTION OF OTHER CD69-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
MLR3 Cosulich E, Genoa  
Leu23 Lanier LL, Palo Alto  

 
SELECTED REFERENCES ON CD69  

REVIEWS

1. Sanchez-Madrid, F. (1995). In: Leukocyte Typing V. (ed. Schlossman et al.) Oxford University Press. 1123-1124. **

2. Testi R,D'Ambrosio D,De Maria R,Santoni A The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells. Immunol Today 1994 15:479 ** PubMed

PRIMARY CITATIONS

3. Cebrian M,Yague E,Rincon M,Lopez-Botet M,de Landazuri MO,Sanchez-Madrid F Triggering of T cell proliferation through AIM, an activation inducer molecule expressed on activated human lymphocytes. J Exp Med 1988 168:1621 * PubMed

4. Lanier LL,Buck DW,Rhodes L,Ding A,Evans E,Barney C,Phillips JH Interleukin 2 activation of natural killer cells rapidly induces the expression and phosphorylation of the Leu-23 activation antigen. J Exp Med 1988 167:1572 * PubMed

5. Lopez-Cabrera M,Munoz E,Blazquez MV,Ursa MA,Santis AG,Sanchez-Madrid F Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements. J Biol Chem 1995 270:21545 * PubMed

6. Lopez-Cabrera M,Santis AG,Fernandez-Ruiz E,Blacher R,Esch F,Sanchez-Mateos P,Sanchez-Madrid F Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors. J Exp Med 1993 178:537 * PubMed

7. Moretta A,Poggi A,Pende D,Tripodi G,Orengo AM,Pella N,Augugliaro R,Bottino C,Ciccone E,Moretta L CD69-mediated pathway of lymphocyte activation: anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolytic T lymphocytes expressing T cell receptor alpha/beta. J Exp Med 1991 174:1393 PubMed

8. Santis AG,Lopez-Cabrera M,Sanchez-Madrid F,Proudfoot N Expression of the early lymphocyte activation antigen CD69, a C-type lectin, is regulated by mRNA degradation associated with AU-rich sequence motifs. Eur J Immunol 1995 25:2142 * PubMed

9. Testi R,Pulcinelli F,Frati L,Gazzaniga PP,Santoni A CD69 is expressed on platelets and mediates platelet activation and aggregation. J Exp Med 1990 172:701 * PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 11/16/99   mpr@mail.nih.gov