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PROW: CD24
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD24
Authors: R. Keith Humphries; Robert Kay; Suzanne Chappel
Reviewer: Peter Altevogt
Link to additional info in FORUM
[GUIDE BAR]

ALTERNATE NAMES FOR CD24  

MAJOR LINKS FOR CD24  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD24  

CELLULAR FUNCTION OF CD24  

DISEASE RELEVANCE OF CD24 AND FUNCTION OF CD24 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD24  

MOLECULAR STRUCTURE OF CD24  

MOLECULAR MASS OF CD24  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
B-lymphocytes 35-45 kDa    

POST-TRANSCRIPTIONAL MODIFICATION OF CD24   - None known

POST-TRANSLATIONAL MODIFICATION OF CD24  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD24   - None known

SUBSTRATES FOR CD24   - No information

ENZYMES WHICH MODIFY CD24   - No information

LIGANDS FOR CD24 AND MOLECULES ASSOCIATED WITH CD24 Link to additional info in FORUM  

MOLECULECOMMENT
P-selectin In mouse and on human carcinomas

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD24 Link to additional info in FORUM  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD24  
REAGENTS
CD24-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
1LD17 (B028)    

SELECTION OF OTHER CD24-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
32D12    
X8 (MA44) Peters, J Hinrich  
ALB 9 (CD24.1) van Agthoven, Andre J  

 
SELECTED REFERENCES ON CD24  

REVIEWS

PRIMARY CITATIONS

1. Aigner S, Sthoeger ZM, Fogel M, Weber E, Zarn J, Ruppert M, Zeller Y, Vestweber D, Stahel R, Sammar M and Altevogt P. CD24, a mucin-type glycoprotein, is a ligand for P-selectin on human tumor cells. Blood 1997 89:3385 ** PubMed

2. Bruce J, Symington FW, McKearn TJ and Sprent J. A monoclonal antibody discriminating between subsets of T and B cells. J. Immunol. 1981 127:2496 PubMed

3. Chappel MS, Hough MR, Mittel A, Takei F, Kay R and Humphries RK. Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes. J. Exp. Med. 1996 184:1638 PubMed

4. Fischer GF, Majdic O, Gadd S and Knapp W. Signal transduction in lymphocytic and myeloid cells via CD24, a new member of phosphoinositol-anchored membrane molecules. J. Immunol. 1990 144:638 PubMed

5. Hahne M, Wenger RH, Vestweber D and Nielsen PJ. The heat-stable antigen can alter very late antigen 4-mediated adhesion. J. Exp. Med. 1994 179:1391 PubMed

6. Hardy RR, Carmack CE, Shinton SA, Kemp JD and Hayakawa K. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 1991 173:1213 PubMed

7. Hough MR, Chappel MS, Sauvageau G, Takei F, Kay R and Humphries RK. Reduction of early B lymphocyte precursors in transgenic mice overexpressing the murine heat-stable antigen. J. Immunol. 1996 156:479 PubMed

8. Hough MR, Takei F, Humphries RK and Kay R. Defective development of thymocytes overexpressing the costimulatory molecule, heat-stable antigen. J. Exp. Med. 1994 179:177 PubMed

9. Jackson D, Waibel R, Weber E, Bell J and Stahel RA. CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas. Cancer Res. 1992 52:5264 PubMed

10. Kadmon G, Eckert M, Sammar M, Schachner M and Altevogt P. Nectadrin, the heat-stable antigen, is a cell adhesion molecule. J. Cell Biol. 1992 118:1245 PubMed

11. Kay R, Rosten PM and Humphries RK. CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor. J. Immunol. 1991 147:1412 PubMed

12. Liu Y, Jones B, Aruffo A, Sullivan KM, Linsley PS and Janeway CA Jr. Heat-stable antigen is a costimulatory molecule for CD4 T cell growth. J. Exp. Med. 1992 175:437 PubMed

13. Sammar M, Aigner S, Hubbe M, Schirrmacher V, Schachner M, Vestweber D and Altevogt P. Heat-stable antigen (CD24) as ligand for mouse P-selectin. Int. Immunol. 1994 6:1027 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov