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PROW: CD21
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD21
Author: Wim Timens
Reviewer: Erwin W. Gelfand
Link to additional info in FORUM
[GUIDE BAR]

ALTERNATE NAMES FOR CD21  

MAJOR LINKS FOR CD21  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD21   - No information

CELLULAR FUNCTION OF CD21 Link to additional info in FORUM  

DISEASE RELEVANCE OF CD21 AND FUNCTION OF CD21 IN INTACT ANIMAL   - Typing of lymphomas


STRUCTURE
MOLECULAR FAMILY FOR CD21  

MOLECULAR STRUCTURE OF CD21  

MOLECULAR MASS OF CD21  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
B cells 145 kDa, 110kDa after endoglycosidase F treatment  
Soluble 130 kDa    

POST-TRANSCRIPTIONAL MODIFICATION OF CD21  

POST-TRANSLATIONAL MODIFICATION OF CD21  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD21   - No information

SUBSTRATES FOR CD21   - No information

ENZYMES WHICH MODIFY CD21   - No information

LIGANDS FOR CD21 AND MOLECULES ASSOCIATED WITH CD21  

MOLECULECOMMENT
C3d Ligand whose binding site located at SCR 1-2 (epitope different from Epstein Barr Virus [EBV])
Soluble crosslinked C3dg SCR 3-4 necessary for high affinity binding of C3dg
CD23 Ligand whose binding site located at SCR 5-8
CD19 See note 1
CD81 See note 1
Leu13 See note 1
Molecule on EBV Ligand whose binding site is located at SCR 1-2

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD21  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD21  
REAGENTS
CD21-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
LT21 A Filatov, Moscow, Rus  
BU80 aka DL Hardie, Birmingham, UK  
BU37 DL Hardie, Birmingham, UK  
BU79 DL Hardie, Birmingham, UK  
BU81 DL Hardie, Birmingham, UK  
DR53 G Delsol, Toulouse, Fr  
5D1 W Zeijlemaker, Amsterdam, NL  

SELECTION OF OTHER CD21-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
B2 Nadler, 1981  
HB5 Tedder, 1984  
OKB7 Knowles, 1984  
BU33 Ling, 1994  
1F8 Petzer, 1988  
5A10 Carel 1990  

 
SELECTED REFERENCES ON CD21  

REVIEWS

1. Cooper NR,Moore MD,Nemerow GR Immunobiology of CR2, the B lymphocyte receptor for Epstein-Barr virus and the C3d complement fragment. Annu Rev Immunol 1988 6:85 PubMed

2. Fearon DT The CD19-CR2-TAPA-1 complex, CD45 and signaling by the antigen receptor of B lymphocytes. Curr Opin Immunol 1993 5:341 PubMed

PRIMARY CITATIONS

3. Carel JC,Myones BL,Frazier B,Holers VM Structural requirements for C3d,g/Epstein-Barr virus receptor (CR2/CD21) ligand binding, internalization, and viral infection. J Biol Chem 1990 265:12293 PubMed

4. Knowles DM 2d,Tolidjian B,Marboe CC,Mittler RS,Talle MA,Goldstein G Distribution of antigens defined by OKB monoclonal antibodies on benign and malignant lymphoid cells and on nonlymphoid tissues. Blood 1984 63:886 PubMed

5. Ling NR,Brown B,Hardie D Synergy test for recognition of epitopes on soluble proteins; its application in the study of CD21 and CD23 antigens and their respective antibodies. J Immunol Methods 1994 173:11 PubMed

6. Nadler LM,Stashenko P,Hardy R,van Agthoven A,Terhorst C,Schlossman SF Characterization of a human B cell-specific antigen (B2) distinct from J Immunol 1981 126:1941 PubMed

7. Paterson RL,Kelleher CA,Streib JE,Amankonah TD,Xu JW,Jones JF,Gelfand EW Activation of human thymocytes after infection by EBV. J Immunol 1995 154:1440 ** PubMed

8. Petzer AL,Schulz TF,Stauder R,Eigentler A,Myones BL,Dierich MP Structural and functional analysis of CR2/EBV receptor by means of monoclonal antibodies and limited tryptic digestion. Immunology 1988 63:47 PubMed

9. Tedder TF,Clement LT,Cooper MD Expression of C3d receptors during human B cell differentiation: immunofluorescence analysis with the HB-5 monoclonal antibody. J Immunol 1984 133:678 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov