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PROW: CD44R
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD44R
Authors: Hua-Xin Liao; Dhavalkumar D. Patel
Reviewer: Paul W. Kincade
[GUIDE BAR]

ALTERNATE NAMES FOR CD44R  

MAJOR LINKS FOR CD44R  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD44R  

CELLULAR FUNCTION OF CD44R  

DISEASE RELEVANCE OF CD44R AND FUNCTION OF CD44R IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD44R  

MOLECULAR STRUCTURE OF CD44R  

MOLECULAR MASS OF CD44R  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Lymphocyte 85-200 kDa    
Epithelial 85-250 kDa    

POST-TRANSCRIPTIONAL MODIFICATION OF CD44R  

POST-TRANSLATIONAL MODIFICATION OF CD44R  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD44R   - Unknown

SUBSTRATES FOR CD44R   - Unknown

ENZYMES WHICH MODIFY CD44R   - Protein kinase C

LIGANDS FOR CD44R AND MOLECULES ASSOCIATED WITH CD44R   - See CD44 CD guide


EXPRESSION
MAIN CELLULAR EXPRESSION OF CD44R  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD44R  
REAGENTS
CD44R-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP   - None

SELECTION OF OTHER CD44R-SPECIFIC REFERENCE MAB   - 11.24 (CD44v9)


 
SELECTED REFERENCES ON CD44R  

REVIEWS

1. Haynes BF,Liao HX,Patton KL The transmembrane hyaluronate receptor (CD44): multiple functions, multiple forms. Cancer Cells 1991 3:347 PubMed

2. Lesley J,Hyman R,Kincade PW CD44 and its interaction with extracellular matrix. Adv Immunol 1993 54:271 PubMed

PRIMARY CITATIONS

3. Bartolazzi A,Nocks A,Aruffo A,Spring F,Stamenkovic I Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan. J Cell Biol 1996 132:1199 PubMed

4. Bennett KL,Jackson DG,Simon JC,Tanczos E,Peach R,Modrell B,Stamenkovic I,Plowman G,Aruffo A CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor. J Cell Biol 1995 128:687 PubMed

5. Jackson DG,Bell JI,Dickinson R,Timans J,Shields J,Whittle N Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon. J Cell Biol 1995 128:673 PubMed

6. Levesque MC,Haynes BF In vitro culture of human peripheral blood monocytes induces hyaluronan binding and up-regulates monocyte variant CD44 isoform expression. J Immunol 1996 156:1557 PubMed

7. Liao HX,Levesque MC,Patton K,Bergamo B,Jones D,Moody MA,Telen MJ,Haynes BF Regulation of human CD44H and CD44E isoform binding to hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies. J Immunol 1993 151:6490 PubMed

8. Mackay CR,Terpe HJ,Stauder R,Marston WL,Stark H,Gunthert U Expression and modulation of CD44 variant isoforms in humans. J Cell Biol 1994 124:71 PubMed

9. Terpe HJ,Koopmann R,Imhof BA,Gunthert U Expression of integrins and CD44 isoforms in non-Hodgkin's lymphomas: CD44 variant isoforms are preferentially expressed in high-grade malignant lymphomas. J Pathol 1994 174:89 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov