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PROW: CD141
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD141
Authors: Michael Chu; Phillip Bird
Reviewer: Edward M. Conway
[GUIDE BAR]

ALTERNATE NAMES FOR CD141  

MAJOR LINKS FOR CD141  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD141  

CELLULAR FUNCTION OF CD141  

DISEASE RELEVANCE OF CD141 AND FUNCTION OF CD141 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD141  

MOLECULAR STRUCTURE OF CD141  

MOLECULAR MASS OF CD141  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Endothelial cells 75 kDa 105 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD141   - CD141 gene has no introns

POST-TRANSLATIONAL MODIFICATION OF CD141  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD141  

SUBSTRATES FOR CD141   - No information

ENZYMES WHICH MODIFY CD141   - No information

LIGANDS FOR CD141 AND MOLECULES ASSOCIATED WITH CD141  

MOLECULECOMMENT
Thrombin Undergoes a conformational change in the reactive center, resulting in the loss of anticoagulant procoagulant function of thrombin *
Protein C Activated by CD141-bound thrombin
Plasma pro-carboxypeptidase B (or TAFI = thrombin activatable fibrinolysis inhibitor) Activated by CD141-bound thrombin **

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD141  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD141  
REAGENTS
CD141-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
1A4 (E013) Teasdale MS et al. 1994  
TMmAb20 (E025) Hidemi Ishii, Teikyo University; Saganiko, Tsukui, Kanagawa 199-01, Japan  
KA-4 (E045) Tomura, S et al. 1994  

SELECTION OF OTHER CD141-SPECIFIC REFERENCE MAB   - No information


 
SELECTED REFERENCES ON CD141  

REVIEWS

1. Bajzar L,Morser J,Nesheim M TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex. J Biol Chem 1996 271:16603 ** PubMed

2. Bird P. 1996. Hematol. Rev. 9:251-274

3. Conway EM,Pollefeyt S,Collen D,Steiner-Mosonyi M The amino terminal lectin-like domain of thrombomodulin is required for constitutive endocytosis. Blood 1997 89:652 ** PubMed

4. Dittman WA,Majerus PW Structure and function of thrombomodulin: a natural anticoagulant. Blood 1990 75:329 PubMed

5. Esmon CT Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface. FASEB J 1995 9:946 ** PubMed

6. Healy AM,Rayburn HB,Rosenberg RD,Weiler H Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system. Proc Natl Acad Sci U S A 1995 92:850 ** PubMed

7. Ohlin AK,Marlar RA The first mutation identified in the thrombomodulin gene in a 45-year- old man presenting with thromboembolic disease. Blood 1995 85:330 ** PubMed

PRIMARY CITATIONS

8. Teasdale MS,Bird CH,Bird P Internalization of the anticoagulant thrombomodulin is constitutive and does not require a signal in the cytoplasmic domain. Immunol Cell Biol 1994 72:480 PubMed

9. Tomura S,Deguchi F,Marumo F,Aoki N Enhanced presence of thrombomodulin in the glomeruli of lupus glomerulonephritis. Clin Nephrol 1994 41:205 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov