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PROW: CD86
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD86
Authors: Deborah L. Hardie; Montserrat Casamayor-Palleja; Ian C. MacLennan
Reviewer: Richard J. Hodes
[GUIDE BAR]

ALTERNATE NAMES FOR CD86  

MAJOR LINKS FOR CD86  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD86  

CELLULAR FUNCTION OF CD86  

DISEASE RELEVANCE OF CD86 AND FUNCTION OF CD86 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD86  

MOLECULAR STRUCTURE OF CD86  

MOLECULAR MASS OF CD86  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Raja   80 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD86   - No information

POST-TRANSLATIONAL MODIFICATION OF CD86  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD86   - No information

SUBSTRATES FOR CD86   - None reported

ENZYMES WHICH MODIFY CD86   - None reported

LIGANDS FOR CD86 AND MOLECULES ASSOCIATED WITH CD86  

MOLECULECOMMENT
CD28 see note 1
CD152 (CTLA-4) see note 1

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD86  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD86   - No information


REAGENTS
CD86-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
B-T11 (86.1) Clement, Diaclone, Besancon, France.  
B-T8 (86.2) Clement  
B-T7 (86.3) Clement  
B-S11 (86.5) Clement  
B-S7 (86.6) Clement  
IT209 (86.7) Engleman, Stanford University, CA  
IT2.2 (86.8) M. Antoinette Reyes, Pharmingen, CA  

SELECTION OF OTHER CD86-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
BU63 Deborah Hardie, Birmingham  
FUN-1 Yoshihiro Nozawa, Fukushima  

 
SELECTED REFERENCES ON CD86  

REVIEWS

1. Hathcock KS,Hodes RJ Role of the CD28-B7 costimulatory pathways in T cell-dependent B cell responses. Adv Immunol 1996 62:131 PubMed

2. June CH,Bluestone JA,Nadler LM,Thompson CB The B7 and CD28 receptor families. Immunol Today 1994 15:321 PubMed

3. Lenschow DJ,Walunas TL,Bluestone JA CD28/B7 system of T cell costimulation. Annu Rev Immunol 1996 14:233 PubMed

4. Townsend SE,Su FW,Atherton JM,Allison JP Specificity and longevity of antitumor immune responses induced by B7- transfected tumors. Cancer Res 1994 54:6477 PubMed

PRIMARY CITATIONS

5. Azuma M,Ito D,Yagita H,Okumura K,Phillips JH,Lanier LL,Somoza C B70 antigen is a second ligand for CTLA-4 and CD28. Nature 1993 366:76 PubMed

6. Borriello F,Sethna MP,Boyd SD,Schweitzer AN,Tivol EA,Jacoby D,Strom TB,Simpson EM,Freeman GJ,Sharpe AH B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity 1997 6:303 PubMed

7. Freeman GJ,Gribben JG,Boussiotis VA,Ng JW,Restivo VA Jr,Lombard LA,Gray GS,Nadler LM Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science 1993 262:909 PubMed

8. Kuchroo VK,Das MP,Brown JA,Ranger AM,Zamvil SS,Sobel RA,Weiner HL,Nabavi N,Glimcher LH B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 1995 80:707 PubMed

9. Lenschow DJ,Zeng Y,Thistlethwaite JR,Montag A,Brady W,Gibson MG,Linsley PS,Bluestone JA Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg. Science 1992 257:789 PubMed

10. Linsley PS,Greene JL,Brady W,Bajorath J,Ledbetter JA,Peach R Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1994 1:793 PubMed

11. Prabhu Das MR,Zamvil SS,Borriello F,Weiner HL,Sharpe AH,Kuchroo VK Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation. Eur J Immunol 1995 25:207 PubMed

12. Ronchese F,Hausmann B,Hubele S,Lane P Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo. J Exp Med 1994 179:809 PubMed

13. Seino K,Azuma M,Bashuda H,Fukao K,Yagita H,Okumura K CD86 (B70/B7-2) on endothelial cells co-stimulates allogeneic CD4+ T cells. Int Immunol 1995 7:1331 PubMed

14. Ueda Y,Levine BL,Huang ML,Freeman GJ,Nadler LM,June CH,Ward SG Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion. Int Immunol 1995 7:957 PubMed

15. Walunas TL,Lenschow DJ,Bakker CY,Linsley PS,Freeman GJ,Green JM,Thompson CB,Bluestone JA CTLA-4 can function as a negative regulator of T cell activation. Immunity 1994 1:405 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

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Modified 10/14/99   mpr@mail.nih.gov