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PROW: CD124
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD124
Author: Kazuo Sugamura
Reviewer: Nobuyuki Harada
[GUIDE BAR]

ALTERNATE NAMES FOR CD124  

MAJOR LINKS FOR CD124  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD124   - No information

CELLULAR FUNCTION OF CD124  

DISEASE RELEVANCE OF CD124 AND FUNCTION OF CD124 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD124  

MOLECULAR STRUCTURE OF CD124  

MOLECULAR MASS OF CD124  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
B-cells 140 kDa    

POST-TRANSCRIPTIONAL MODIFICATION OF CD124  

POST-TRANSLATIONAL MODIFICATION OF CD124  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD124   - No information

SUBSTRATES FOR CD124   - No information**

ENZYMES WHICH MODIFY CD124   - No information**

LIGANDS FOR CD124 AND MOLECULES ASSOCIATED WITH CD124  

MOLECULECOMMENT
Interleukin 4 Ligand
Interleukin 13 Ligand
CD132 (IL-2 receptor gamma chain) High-affinity IL-4 receptor consists of CD124 and CD132
IL-13 receptor beta chain High-affinity IL-13 receptor consists of CD124 and IL-13R beta
Jak1 Tyrosine kinase associated with the cytoplasmic domain of CD124
Fes Tyrosine kinase associated with the cytoplasmic domain of CD124
Stat6 Associated with the cytoplasmic domain of CD124 after IL-4 stimulation
IRS-2 (4PS) Associated with the cytoplasmic domain of CD124 after IL-4 stimulation

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD124  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD124   - No information


REAGENTS
CD124-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
S456C9 (C-4) van Agthoven  

SELECTION OF OTHER CD124-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
hIL-4R-M57 RJ Armitage, Seattle  

 
SELECTED REFERENCES ON CD124  

REVIEWS

1. Keegan AD,Nelms K,Wang LM,Pierce JH,Paul WE Interleukin 4 receptor: signaling mechanisms. Immunol Today 1994 15:423 PubMed

PRIMARY CITATIONS

2. Harada N,Castle BE,Gorman DM,Itoh N,Schreurs J,Barrett RL,Howard M,Miyajima A Expression cloning of a cDNA encoding the murine interleukin 4 receptor based on ligand binding. Proc Natl Acad Sci U S A 1990 87:857 PubMed

3. Idzerda RL,March CJ,Mosley B,Lyman SD,Vanden Bos T,Gimpel SD,Din WS,Grabstein KH,Widmer MB,Park LS,et al Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily. J Exp Med 1990 171:861 PubMed

4. Mosley B,Beckmann MP,March CJ,Idzerda RL,Gimpel SD,VandenBos T,Friend D,Alpert A,Anderson D,Jackson J,et al The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms. Cell 1989 59:335 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov