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PROW: CD74
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD74
Author: Peter Moeller
Reviewer: Norbert Koch
[GUIDE BAR]

ALTERNATE NAMES FOR CD74  

MAJOR LINKS FOR CD74  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD74   - No information

CELLULAR FUNCTION OF CD74  

DISEASE RELEVANCE OF CD74 AND FUNCTION OF CD74 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD74  

MOLECULAR STRUCTURE OF CD74  

MOLECULAR MASS OF CD74  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Various 33 kDa, 35 kDa, (41kDa)   Isoforms

POST-TRANSCRIPTIONAL MODIFICATION OF CD74  

POST-TRANSLATIONAL MODIFICATION OF CD74  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD74  
MOLECULECOMMENT
NFkB The promoter region of the Ii gene has two NFkb binding sites*

SUBSTRATES FOR CD74   - Not known

ENZYMES WHICH MODIFY CD74  

MOLECULECOMMENT
Cathepsin S Within the MHC class II loading compartment*; then HLA-DM removes CLIP

LIGANDS FOR CD74 AND MOLECULES ASSOCIATED WITH CD74  

MOLECULECOMMENT
HLA-DR heterodimers cf 11
CD44 Single observation not yet been confirmed by other lab

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD74  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD74   - No information


REAGENTS
CD74-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
SN10 (B064) Ben K Seon, Buffalo, NY  

SELECTION OF OTHER CD74-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
BY2 (CD74.1) Karen Pulford, Oxford, UK  
BU-45 (CD74.2) Deborah L Hardie, Birmingham, UK  
BU-43 (CD74.6) Deborah L Hardie, Birmingham, UK  
M-B741 (CD74) Peter Rieber, Dresden, FRG  

 
SELECTED REFERENCES ON CD74  

REVIEWS

1. Cresswell P Assembly, transport, and function of MHC class II molecules. Annu Rev Immunol 1994 12:259 PubMed

PRIMARY CITATIONS

2. Bakke O,Dobberstein B MHC class II-associated invariant chain contains a sorting signal for endosomal compartments. Cell 1990 63:707 PubMed

3. Freisewinkel IM,Schenck K,Koch N The segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptides. Proc Natl Acad Sci U S A 1993 90:9703 PubMed

4. Ghosh P,Amaya M,Mellins E,Wiley DC The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature 1995 378:457 PubMed

5. Koch N,Moldenhauer G,Hofmann WJ,Moller P Rapid intracellular pathway gives rise to cell surface expression of the MHC class II-associated invariant chain (CD74). J Immunol 1991 147:2643 PubMed

6. Lotteau V,Teyton L,Peleraux A,Nilsson T,Karlsson L,Schmid SL,Quaranta V,Peterson PA Intracellular transport of class II MHC molecules directed by invariant chain. Nature 1990 348:600 PubMed

7. Roche PA,Cresswell P Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding. Nature 1990 345:615 PubMed

8. Stockinger B,Pessara U,Lin RH,Habicht J,Grez M,Koch N A role of Ia-associated invariant chains in antigen processing and presentation. Cell 1989 56:683 PubMed

9. Strubin M,Long EO,Mach B Two forms of the Ia antigen-associated invariant chain result from alternative initiations at two in-phase AUGs. Cell 1986 47:619 PubMed

10. Viville S,Neefjes J,Lotteau V,Dierich A,Lemeur M,Ploegh H,Benoist C,Mathis D Mice lacking the MHC class II-associated invariant chain. Cell 1993 72:635 PubMed

11. Wraight CJ,van Endert P,Moller P,Lipp J,Ling NR,MacLennan IC,Koch N,Moldenhauer G Human major histocompatibility complex class II invariant chain is expressed on the cell surface. J Biol Chem 1990 265:5787 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov