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PROW: CD38
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PROW and IWHLDA present the GUIDE on:
CD38
Authors: Fabio Malavasi; Enza Ferrero
Reviewer: Hon Cheung Lee
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ALTERNATE NAMES FOR CD38  

MAJOR LINKS FOR CD38  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD38  

CELLULAR FUNCTION OF CD38  

DISEASE RELEVANCE OF CD38 AND FUNCTION OF CD38 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD38  

MOLECULAR STRUCTURE OF CD38  

MOLECULAR MASS OF CD38  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Leukocytes 45 kDa 45 kDa  
HL-60   45kDa, 190 kDa After all-trans-retinoic acid (ATRA) differentiation
Soluble form 39 kDa 39 kDa  
Soluble form 78 kDa 78 kDa In X-linked agammaglobulinemia (XLA)-derived B cell lines

POST-TRANSCRIPTIONAL MODIFICATION OF CD38  

POST-TRANSLATIONAL MODIFICATION OF CD38  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD38  
MOLECULECOMMENT
Retinoids in HL-60 myeloid cell line Upregulation
Vitamin D3 in Jurkat T cell line Upregulation
g-interferon in human monocytes Upregulation

SUBSTRATES FOR CD38  

MOLECULECOMMENT
Beta-nicotinamide adenine dinucleotide (beta-NAD+)  
Beta-nicotinamide adenine dinucleotide phosphate (beta-NADP)  
Cyclic ADP-ribose (cADPR)**  

ENZYMES WHICH MODIFY CD38   - No information

LIGANDS FOR CD38 AND MOLECULES ASSOCIATED WITH CD38  

MOLECULECOMMENT
CD31 Binds CD38
Hyaluronic acid Binds CD38
T cell receptor (TCR)/CD3 See NOTE
B cell receptor (BCR) See NOTE
CD16 See NOTE
CD73 See NOTE
PC-1 See NOTE
CD26 See NOTE

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD38  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD38  
REAGENTS
CD38-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
AT 13/5 (CD38.1) MK Broe  
L4 (CD38.2) K Kikuchi  

SELECTION OF OTHER CD38-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
IB4 Malavasi et al. 1984  
OKT10 ATCC  
HB7 Cooper MD et al.  

 
SELECTED REFERENCES ON CD38  

REVIEWS

1. Ferrero E; Malavasi F. The metamorphosis of a molecule: from soluble enzyme to the leukocyte receptor CD38. J. Leukoc. Biol. 1999 65:151 PubMed

2. Lund F; Solvason N; Grimaldi JC; Parkhouse RM; Howard M. Murine CD38: an immunoregulatory ectoenzyme. Immunol. Today 1995 16:469 PubMed

3. Malavasi F; Funaro A; Roggero S; Horenstein A; Calosso L; Mehta K. Human CD38: a glycoprotein in search of a function. Immunol. Today 1994 15:95 PubMed

4. Mehta K; Shahid U; Malavasi F. Human CD38, a cell-surface protein with multiple functions. FASEB J. 1996 10:1408 PubMed

5. Shubinsky G; Schlesinger M. The CD38 lymphocyte differentiation marker: new insight into its ectoenzymatic activity and its role as a signal transducer. Immunity 1997 7:315 PubMed

PRIMARY CITATIONS

6. Aarhus R; Graeff RM; Dickey DM; Walseth TF; Lee HC. ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADP. J. Biol. Chem. 1995 270:30327 ** PubMed

7. Cesano A; Visonneau S; Deaglio S; Malavasi F; Santoli D. Role of CD38 and its ligand in the regulation of MHC-nonrestricted cytotoxic T cells. J. Immunol. 1998 160:1106 PubMed

8. Cockayne DA; Muchamuel T; Grimaldi JC; Muller-Steffner H; Randall TD; Lund FE; Murray R; Schuber F; Howard MC. Mice deficient for the ecto-nicotinamide adenine dinucleotide glycohydrolase CD38 exhibit altered humoral immune responses. Blood 1998 92:1324 PubMed

9. Deaglio S; Morra M; Mallone R; Ausiello CM; Prager E; Garbarino G; Dianzani U; Stockinger H; Malavasi F. Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member. J. Immunol. 1998 160:395 PubMed

10. Deterre P; Gelman L; Gary-Gouy H; Arrieumerlou C; Berthelier V; Tixier JM; Ktorza S; Goding J; Schmitt C; Bismuth G. Coordinated regulation in human T cells of nucleotide-hydrolyzing ecto-enzymatic activities, including CD38 and PC-1. Possible role in the recycling of nicotinamide adenine dinucleotide metabolites. J. Immunol. 1996 157:1381 PubMed

11. Ferrero E; Malavasi F. Human CD38, a leukocyte receptor and ectoenzyme, is a member of a novel eukaryotic gene family of nicotinamide adenine dinucleotide+-converting enzymes: extensive structural homology with the genes for murine bone marrow stromal cell antigen 1 and aplysian ADP-ribosyl cyclase. J. Immunol. 1997 159:3858 PubMed

12. Ferrero E; Saccucci F; Malavasi F. The human CD38 gene: polymorphism, CpG island, and linkage to the CD157 (BST-1) gene. Immunogenetics 1999 49:597 PubMed

13. Funaro A; Reinis M; Trubiani O; Santi S; Di Primio R; Malavasi F. CD38 functions are regulated through an internalization step. J. Immunol. 1998 160:2238 PubMed

14. Hoshino S; Kukimoto I; Kontani K; Inoue S; Kanda Y; Malavasi F; Katada T. Mapping of the catalytic and epitopic sites of human CD38/NAD+ glycohydrolase to a functional domain in the carboxyl terminus. J. Immunol. 1997 158:741 PubMed

15. Howard M; Grimaldi JC; Bazan JF; Lund FE; Santos-Argumedo L; Parkhouse RM; Walseth TF; Lee HC. Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38. Science 1993 262:1056 PubMed

16. Ikehata F; Satoh J; Nata K; Tohgo A; Nakazawa T; Kato I; Kobayashi S; Akiyama T; Takasawa S; Toyota T; Okamoto H. Autoantibodies against CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) that impair glucose-induced insulin secretion in noninsulin- dependent diabetes patients. J. Clin. Invest. 1998 102:395 PubMed

17. Kato I; Yamamoto Y; Fujimura M; Noguchi N; Takasawa S; Okamoto H. CD38 disruption impairs glucose-induced increases in cyclic ADP-ribose, [Ca2+]i, and insulin secretion. J. Biol. Chem. 1999 274:1869 PubMed

18. Kitanaka A; Suzuki T; Ito C; Nishigaki H; Coustan-Smith E; Tanaka T; Kubota Y; Campana D. CD38-mediated signaling events in murine pro-B cells expressing human CD38 with or without its cytoplasmic domain. J. Immunol. 1999 162:1952 PubMed

19. Kontani K; Nishina H; Ohoka Y; Takahashi K; Katada T. NAD glycohydrolase specifically induced by retinoic acid in human leukemic HL-60 cells. Identification of the NAD glycohydrolase as leukocyte cell surface antigen CD38. J. Biol. Chem. 1993 268:16895 PubMed

20. Mallone R; Ferrua S; Morra M; Zocchi E; Mehta K; Notarangelo LD; Malavasi F. Characterization of a CD38-like 78-kilodalton soluble protein released from B cell lines derived from patients with X-linked agammaglobulinemia. J. Clin. Invest. 1998 101:2821 PubMed

21. Morra M; Zubiaur M; Terhorst C; Sancho J; Malavasi F. CD38 is functionally dependent on the TCR/CD3 complex in human T cells. FASEB J. 1998 12:581 PubMed

22. Nata K; Takamura T; Karasawa T; Kumagai T; Hashioka W; Tohgo A; Yonekura H; Takasawa S; Nakamura S; Okamoto H. Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing. Gene 1997 186:285 PubMed

23. Prasad GS; McRee DE; Stura EA; Levitt DG; Lee HC; Stout CD. Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38. Nat. Struct. Biol. 1996 3:957 PubMed

24. States DJ; Walseth TF; Lee HC. Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38. Trends Biochem. Sci. 1992 17:495 PubMed

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* indicates ammended by reviewer, ** indicates added by reviewer

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Modified 10/25/99   mpr@mail.nih.gov