Science Gateway > Resources > Cluster of Differentiation Index

PROW: CD162
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD162
Author: Kiyoshi Goda
Reviewer: Rodger P. McEver
[GUIDE BAR]

ALTERNATE NAMES FOR CD162  

MAJOR LINKS FOR CD162  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD162   - Unknown

CELLULAR FUNCTION OF CD162  

DISEASE RELEVANCE OF CD162 AND FUNCTION OF CD162 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD162  

MOLECULAR STRUCTURE OF CD162  

MOLECULAR MASS OF CD162  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Neutrophil 250kDa, 160kDa 120kDa  
HL60 220kDa 110kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD162  

POST-TRANSLATIONAL MODIFICATION OF CD162  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD162   - Unknown

SUBSTRATES FOR CD162   - Unknown

ENZYMES WHICH MODIFY CD162   - Unknown

LIGANDS FOR CD162 AND MOLECULES ASSOCIATED WITH CD162  

MOLECULECOMMENT
CD62P  
CD62E  
CD62L **  

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD162  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD162  
REAGENTS
CD162-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
PL1 (A042) Moore KL / McEver RP, Oklahoma City  
PL2 (A043) Moore KL / McEver RP, Oklahoma City  

SELECTION OF OTHER CD162-SPECIFIC REFERENCE MAB   - None


 
SELECTED REFERENCES ON CD162  

REVIEWS

PRIMARY CITATIONS

1. Moore KL,Stults NL,Diaz S,Smith DF,Cummings RD,Varki A,McEver RP Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells. J Cell Biol 1992 118:445 PubMed

2. Norgard KE,Moore KL,Diaz S,Stults NL,Ushiyama S,McEver RP,Cummings RD,Varki A Characterization of a specific ligand for P-selection on myeloid cells. A minor glycoprotein with sialylated O-linked oligosaccharides. J Biol Chem 1993 268:12764 PubMed

3. Wilkins PP,Moore KL,McEver RP,Cummings RD Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin. J Biol Chem 1995 270:22677 PubMed

4. Pouyani T,Seed B PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus. Cell 1995 83:333 PubMed

5. Sako D,Comess KM,Barone KM,Camphausen RT,Cumming DA,Shaw GD A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding. Cell 1995 83:323 PubMed

6. Li F,Wilkins PP,Crawley S,Weinstein J,Cummings RD,McEver RP Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectin. J Biol Chem 1996 271:3255 PubMed

7. Spertini O,Cordey AS,Monai N,Giuffre L,Schapira M P-selectin glycoprotein ligand 1 is a ligand for L-selectin on neutrophils, monocytes, and CD34+ hematopoietic progenitor cells. J Cell Biol 1996 135:523 PubMed

8. Li F,Erickson HP,James JA,Moore KL,Cummings RD,McEver RP Visualization of P-selection glycoprotein ligand-1 as a highly extended molecule and mapping of protein epitopes for monoclonal antibodies. J Biol Chem 1996 271:6342 PubMed

9. Guyer DA,Moore KL,Lynam EB,Schammel CM,Rogelj S,McEver RP,Sklar LA P-selectin glycoprotein ligand-1 (PSGL-1) is a ligand for L-selectin in neutrophil aggregation. Blood 1996 88:2415 PubMed

10. Walcheck B,Moore KL,McEver RP,Kishimoto TK Neutrophil-neutrophil interactions under hydrodynamic shear stress involve L-selectin and PSGL-1. A mechanism that amplifies initial leukocyte accumulation of P-selectin in vitro. J Clin Invest 1996 98:1081 PubMed

11. Laszik Z,Jansen PJ,Cummings RD,Tedder TF,McEver RP,Moore KL P-selectin glycoprotein ligand-1 is broadly expressed in cells of myeloid, lymphoid, and dendritic lineage and in some nonhematopoietic cells. Blood 1996 88:3010 PubMed

12. Tu L,Chen A,Delahunty MD,Moore KL,Watson SR,McEver RP,Tedder TF L-selectin binds to P-selectin glycoprotein ligand-1 on leukocytes: interactions between the lectin, epidermal growth factor, and consensus repeat domains of the selectins determine ligand binding specificity. J Immunol 1996 157:3995 ** PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov