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PROW: CD117
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PROW and IWHLDA present the GUIDE on:
CD117
Author: Leonie K. Ashman
Reviewer: Hans-Joerg Buehring
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ALTERNATE NAMES FOR CD117  

MAJOR LINKS FOR CD117  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD117  

CELLULAR FUNCTION OF CD117   - Growth factor receptor

DISEASE RELEVANCE OF CD117 AND FUNCTION OF CD117 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD117  

MOLECULAR STRUCTURE OF CD117  

MOLECULAR MASS OF CD117  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
AML cells, cell lines 145 kDa 145 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD117  

POST-TRANSLATIONAL MODIFICATION OF CD117  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD117   - No information

SUBSTRATES FOR CD117  

MOLECULECOMMENT
PI 3 kinase p85 regulatory subunit See note 1
PLCg1 See note 1
Tec kinase See note 1
Shc See note 1
Vav See note 1

ENZYMES WHICH MODIFY CD117  

MOLECULECOMMENT
SHP phosphatase (Paulson R et al. 1996)
Protein kinase C (Blume-Jensen P et al. 1995). May down-regulate Kit signaling

LIGANDS FOR CD117 AND MOLECULES ASSOCIATED WITH CD117  


EXPRESSION
MAIN CELLULAR EXPRESSION OF CD117  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD117  
REAGENTS
CD117-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
A3C6E2 (C6) Buehring HJ, Tuebingen, Germany  
57A5 (C29) Buehring HJ, Tuebingen, Germany  
104D2 (C30) Buehring HJ, Tuebingen, Germany  
KIT3 (C44) Ashman LK, Adelaide, Australia  
NU-C-KIT (C45) Nakamura M, Japan  
L15 (C46) Nakamura M, Japan  
MTK1 (C68) Morita S, Tohoku, Japan  

SELECTION OF OTHER CD117-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
YB5.B8 (Workshop V; Buehring HJ et al. 1995)  
17F11 (Workshop V; Buehring HJ et al. 1995)  
95C3 (Workshop V; Buehring HJ et al. 1995)  
1D5.E11 (Workshop V; Buehring HJ et al. 1995)  
3B1.B8 (Workshop V; Buehring HJ et al. 1995)  
1A2.C5 (Workshop V; Buehring HJ et al. 1995)  
1C1.HF (Workshop V; Buehring HJ et al. 1995)  
SR1 (c.f. Buehring HJ et al, 1995)  
3D6 (c.f. Buehring HJ et al, 1995)  
1DC3 (c.f. Buehring HJ et al, 1995)  

 
SELECTED REFERENCES ON CD117  

REVIEWS

1. Buhring, H-J, Ashman LK, Gattei V, Kniep B, Larregina A, Pinto A, Valent P and van den Oord JJ. 1995. in Schlossman SF et al. (eds) Leucocyte Typing V, Oxford University Press, Oxford, 1882-1888.

2. Galli SJ,Zsebo KM,Geissler EN The kit ligand, stem cell factor. Adv Immunol 1994 55:1 PubMed

PRIMARY CITATIONS

3. Adachi S,Ebi Y,Nishikawa S,Hayashi S,Yamazaki M,Kasugai T,Yamamura T,Nomura S,Kitamura Y Necessity of extracellular domain of W (c-kit) receptors for attachment of murine cultured mast cells to fibroblasts. Blood 1992 79:650 PubMed

4. Ashman LK,Cambareri AC,To LB,Levinsky RJ,Juttner CA Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow. Blood 1991 78:30 PubMed

5. Besmer P,Murphy JE,George PC,Qiu FH,Bergold PJ,Lederman L,Snyder HW Jr,Brodeur D,Zuckerman EE,Hardy WD A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family. Nature 1986 320:415 PubMed

6. Blume-Jensen P,Wernstedt C,Heldin CH,Ronnstrand L Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells. J Biol Chem 1995 270:14192 PubMed

7. Buhring HJ,Ullrich A,Schaudt K,Muller CA,Busch FW The product of the proto-oncogene c-kit (P145c-kit) is a human bone marrow surface antigen of hemopoietic precursor cells which is expressed on a subset of acute non-lymphoblastic leukemic cells. Leukemia 1991 5:854 PubMed

8. Crosier PS,Ricciardi ST,Hall LR,Vitas MR,Clark SC,Crosier KE Expression of isoforms of the human receptor tyrosine kinase c-kit in leukemic cell lines and acute myeloid leukemia. Blood 1993 82:1151 PubMed

9. Gadd SJ,Ashman LK A murine monoclonal antibody specific for a cell-surface antigen expressed by a subgroup of human myeloid leukaemias. Leuk Res 1985 9:1329 PubMed

10. Hibi K,Takahashi T,Sekido Y,Ueda R,Hida T,Ariyoshi Y,Takagi H,Takahashi T Coexpression of the stem cell factor and the c-kit genes in small-cell lung cancer. Oncogene 1991 6:2291 PubMed

11. Lerner NB,Nocka KH,Cole SR,Qiu FH,Strife A,Ashman LK,Besmer P Monoclonal antibody YB5.B8 identifies the human c-kit protein product. Blood 1991 77:1876 PubMed

12. Lev S,Givol D,Yarden Y A specific combination of substrates is involved in signal transduction by the kit-encoded receptor. EMBO J 1991 10:647 PubMed

13. Matsuguchi T,Inhorn RC,Carlesso N,Xu G,Druker B,Griffin JD Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM- CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL. EMBO J 1995 14:257 PubMed

14. Mayrhofer G,Gadd SJ,Spargo LD,Ashman LK Specificity of a mouse monoclonal antibody raised against acute myeloid leukaemia cells for mast cells in human mucosal and connective tissues. Immunol Cell Biol 1987 65:241 PubMed

15. Nagata H,Worobec AS,Oh CK,Chowdhury BA,Tannenbaum S,Suzuki Y,Metcalfe DD Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc Natl Acad Sci U S A 1995 92:10560 PubMed

16. Paulson RF,Vesely S,Siminovitch KA,Bernstein A Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1. Nat Genet 1996 13:309 PubMed

17. Tang B,Mano H,Yi T,Ihle JN Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding. Mol Cell Biol 1994 14:8432 PubMed

18. Turner AM,Bennett LG,Lin NL,Wypych J,Bartley TD,Hunt RW,Atkins HL,Langley KE,Parker V,Martin F,et al Identification and characterization of a soluble c-kit receptor produced by human hematopoietic cell lines. Blood 1995 85:2052 PubMed

19. Witte ON Steel locus defines new multipotent growth factor. Cell 1990 63:5 PubMed

20. Yarden Y,Kuang WJ,Yang-Feng T,Coussens L,Munemitsu S,Dull TJ,Chen E,Schlessinger J,Francke U,Ullrich A Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 1987 6:3341 PubMed

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Modified 10/14/99   mpr@mail.nih.gov