Science Gateway > Resources > Cluster of Differentiation Index

PROW: CD122
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD122
Author: Kazuo Sugamura
Reviewer: Thomas A. Waldmann
[GUIDE BAR]

ALTERNATE NAMES FOR CD122  

MAJOR LINKS FOR CD122  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD122  

CELLULAR FUNCTION OF CD122  

DISEASE RELEVANCE OF CD122 AND FUNCTION OF CD122 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD122  

MOLECULAR STRUCTURE OF CD122  

MOLECULAR MASS OF CD122  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Lymphocytes 70-75 kDa    

POST-TRANSCRIPTIONAL MODIFICATION OF CD122   - No information

POST-TRANSLATIONAL MODIFICATION OF CD122  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD122   - No information

SUBSTRATES FOR CD122   - No information

ENZYMES WHICH MODIFY CD122   - No information

LIGANDS FOR CD122 AND MOLECULES ASSOCIATED WITH CD122  

MOLECULECOMMENT
Interleukin-2 A ligand secreted by activated T cells
Interleukin-15 A ligand whose mRNA is expressed by skeletal muscle, placenta kidney, fibroblasts and activated monocytes*
CD25 (IL-2R alpha) High-affinity IL-2R consists of CD25, CD122 and CD132
CD132 (IL-2R gamma, gamma chain) High-affinity IL-2R consists of CD25, CD122 and CD132
Syk Tyrosine kinase are associated with the cytoplasmic region of CD122
Lck Tyrosine kinase are associated with the cytoplasmic region of CD122
Jak1 Tyrosine kinase are associated with the cytoplasmic region of CD122
Stat5 Associated with the cytoplasmic region of CD122

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD122  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD122   - No information


REAGENTS
CD122-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP   - None

SELECTION OF OTHER CD122-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
Mik-beta 1 Tsudo M et al. 1982,1989  
TU27 Takeshita T et al. 1989  

 
SELECTED REFERENCES ON CD122  

REVIEWS

1. Minami Y,Kono T,Miyazaki T,Taniguchi T The IL-2 receptor complex: its structure, function, and target genes. Annu Rev Immunol 1993 11:245 ** PubMed

2. Sugamura K,Asao H,Kondo M,Tanaka N,Ishii N,Nakamura M,Takeshita T The common gamma-chain for multiple cytokine receptors. Adv Immunol 1995 59:225 PubMed

3. Waldmann TA The interleukin-2 receptor. J Biol Chem 1991 266:2681 ** PubMed

PRIMARY CITATIONS

4. Hatakeyama M,Tsudo M,Minamoto S,Kono T,Doi T,Miyata T,Miyasaka M,Taniguchi T Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's. Science 1989 244:551 PubMed

5. Sharon M,Klausner RD,Cullen BR,Chizzonite R,Leonard WJ Novel interleukin-2 receptor subunit detected by cross-linking under Science 1986 234:859 ** PubMed

6. Suzuki H,Kundig TM,Furlonger C,Wakeham A,Timms E,Matsuyama T,Schmits R,Simard JJ,Ohashi PS,Griesser H,et al Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science 1995 268:1472 ** PubMed

7. Takeshita T,Goto Y,Tada K,Nagata K,Asao H,Sugamura K Monoclonal antibody defining a molecule possibly identical to the p75 subunit of interleukin 2 receptor. J Exp Med 1989 169:1323 PubMed

8. Tsudo M,Kitamura F,Miyasaka M Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies. Proc Natl Acad Sci U S A 1989 86:1982 PubMed

9. Tsudo M,Kozak RW,Goldman CK,Waldmann TA Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex. Proc Natl Acad Sci U S A 1986 83:9694 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov