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PROW: CD62E
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PROW and IWHLDA present the GUIDE on:
CD62E
Author: Kiyoshi Goda
Reviewers: Michael A. Gimbrone; David Milstone
[GUIDE BAR]

ALTERNATE NAMES FOR CD62E  

MAJOR LINKS FOR CD62E  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD62E   - Unknown

CELLULAR FUNCTION OF CD62E  

DISEASE RELEVANCE OF CD62E AND FUNCTION OF CD62E IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD62E  

MOLECULAR STRUCTURE OF CD62E  

MOLECULAR MASS OF CD62E  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
IL-1 treated endothelial cells (HEC, HUVEC)*   115 kDa, 97 kDa  
CD62E-transfected COS cells   107 kDa, 97 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD62E   - Unknown

POST-TRANSLATIONAL MODIFICATION OF CD62E  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD62E  
MOLECULECOMMENT
AP-1  
NF-kB  
TF-2**  
HMGI (Y)**  

SUBSTRATES FOR CD62E   - Unknown

ENZYMES WHICH MODIFY CD62E   - Unknown

LIGANDS FOR CD62E AND MOLECULES ASSOCIATED WITH CD62E  

MOLECULECOMMENT
Sialyl Lewis x  
Sialyl Lewis a  
ESL-1 (mouse)  
CLA (cutaneous leukocyte antigen  
CD162 (PSGL-1)  

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD62E  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD62E   - No information


REAGENTS
CD62E-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
B-K6 (A061) Vermot-Desroches C / Wijdenes J, Besancon  
B-P7 (A067) Vermot-Desroches C / Wijdenes J, Besancon  
B-P11 (A068) Vermot-Desroches C / Wijdenes J, Besancon  
B-S3 (A074) Vermot-Desroches C / Wijdenes J, Besancon  
68-5H11 (A090) Vadas MA, Adelaide  

SELECTION OF OTHER CD62E-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
1.2B6 Graber N et al. 1990  
BBIg-E4 Pigott R et al. 1991  
H4/18 Pober et al. 1986**  
H18/7 Bevilacqua et al. 1987**  

 
SELECTED REFERENCES ON CD62E  

REVIEWS

PRIMARY CITATIONS

1. Berg EL,Yoshino T,Rott LS,Robinson MK,Warnock RA,Kishimoto TK,Picker LJ,Butcher EC The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1. J Exp Med 1991 174:1461 PubMed

2. Bevilacqua MP,Pober JS,Mendrick DL,Cotran RS,Gimbrone MA Jr Identification of an inducible endothelial-leukocyte adhesion molecule. Proc Natl Acad Sci U S A 1987 84:9238 ** PubMed

3. Bevilacqua MP,Stengelin S,Gimbrone MA Jr,Seed B Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science 1989 243:1160 PubMed

4. Carlos T,Kovach N,Schwartz B,Rosa M,Newman B,Wayner E,Benjamin C,Osborn L,Lobb R,Harlan J Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells: endothelial-leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1. Blood 1991 77:2266 PubMed

5. Cotran RS,Gimbrone MA Jr,Bevilacqua MP,Mendrick DL,Pober JS Induction and detection of a human endothelial activation antigen in vivo. J Exp Med 1986 164:661 PubMed

6. Groves RW,Allen MH,Barker JN,Haskard DO,MacDonald DM Endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in cutaneous inflammation. Br J Dermatol 1991 124:117 PubMed

7. Koch AE,Burrows JC,Haines GK,Carlos TM,Harlan JM,Leibovich SJ Immunolocalization of endothelial and leukocyte adhesion molecules in human rheumatoid and osteoarthritic synovial tissues. Lab Invest 1991 64:313 PubMed

8. Koch AE,Halloran MM,Haskell CJ,Shah MR,Polverini PJ Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1. Nature 1995 376:517 PubMed

9. Lawrence MB,Springer TA Neutrophils roll on E-selectin. J Immunol 1993 151:6338 PubMed

10. Pober JS,Bevilacqua MP,Mendrick DL,Lapierre LA,Fiers W,Gimbrone MA Jr Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells. J Immunol 1986 136:1680 PubMed

11. Walz G,Aruffo A,Kolanus W,Bevilacqua M,Seed B Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells. Science 1990 250:1132 PubMed

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* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov