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PROW: CD56
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PROW and IWHLDA present the GUIDE on:
CD56
Author: Alessandro Poggi
Reviewer: Lewis L. Lanier
[GUIDE BAR]

ALTERNATE NAMES FOR CD56  

MAJOR LINKS FOR CD56  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD56   - No information

CELLULAR FUNCTION OF CD56  

DISEASE RELEVANCE OF CD56 AND FUNCTION OF CD56 IN INTACT ANIMAL   - No information


STRUCTURE
MOLECULAR FAMILY FOR CD56  

MOLECULAR STRUCTURE OF CD56  

MOLECULAR MASS OF CD56  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
NK cells and T cells 175-220 kDa    

POST-TRANSCRIPTIONAL MODIFICATION OF CD56  

POST-TRANSLATIONAL MODIFICATION OF CD56  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD56   - No information

SUBSTRATES FOR CD56   - No information

ENZYMES WHICH MODIFY CD56   - No information

LIGANDS FOR CD56 AND MOLECULES ASSOCIATED WITH CD56  

MOLECULECOMMENT
NCAM-1 CD56 (NCAM) mediates homophilic adhesion in certain cell types
Heparin sulfate Another putative ligand

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD56  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD56  
REAGENTS
CD56-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
C218 van Aghtoven A/Marseille  
42.18 Reisbach G/Munchen  
MEM188 Horejsi, V/Praha  
MOC-1 De Jonge WAM/Groninghen  

SELECTION OF OTHER CD56-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
Leu19 Lanier LL et al. 1989  
N901 Ritz et al. 1988  

 
SELECTED REFERENCES ON CD56  

REVIEWS

PRIMARY CITATIONS

1. Thiery JP,Duband JL,Rutishauser U,Edelman GM Cell adhesion molecules in early chicken embryogenesis. Proc Natl Acad Sci U S A 1982 79:6737 PubMed

2. Rutishauser U,Grumet M,Edelman GM Neural cell adhesion molecule mediates initial interactions between spinal cord neurons and muscle cells in culture. J Cell Biol 1983 97:145 PubMed

3. Lanier LL,Testi R,Bindl J,Phillips JH Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule. J Exp Med 1989 169:2233 PubMed

4. Hercend T,Griffin JD,Bensussan A,Schmidt RE,Edson MA,Brennan A,Murray C,Daley JF,Schlossman SF,Ritz J Generation of monoclonal antibodies to a human natural killer clone. Characterization of two natural killer-associated antigens, NKH1A and NKH2, expressed on subsets of large granular lymphocytes. J Clin Invest 1985 75:932 PubMed

5. Cunningham BA,Hemperly JJ,Murray BA,Prediger EA,Brackenbury R,Edelman GM Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing. Science 1987 236:799 PubMed

6. Barton CH,Dickson G,Gower HJ,Rowett LH,Putt W,Elsom V,Moore SE,Goridis C,Walsh FS Complete sequence and in vitro expression of a tissue-specific phosphatidylinositol-linked N-CAM isoform from skeletal muscle. Development 1988 104:165 PubMed

7. Lanier LL,Chang C,Azuma M,Ruitenberg JJ,Hemperly JJ,Phillips JH Molecular and functional analysis of human natural killer cell- associated neural cell adhesion molecule (N-CAM/CD56). J Immunol 1991 146:4421 PubMed

8. Hemperly JJ,DeGuglielmo JK,Reid RA Characterization of cDNA clones defining variant forms of human neural cell adhesion molecule N-CAM. J Mol Neurosci 1990 2:71 PubMed

9. Cremer H,Lange R,Christoph A,Plomann M,Vopper G,Roes J,Brown R,Baldwin S,Kraemer P,Scheff S,et al Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning. Nature 1994 367:455 PubMed

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* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov