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PROW: CD26
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PROW and IWHLDA present the GUIDE on:
CD26
Author: Martin Hegen
Reviewer: Tamas Oravecz
[GUIDE BAR]

ALTERNATE NAMES FOR CD26  

MAJOR LINKS FOR CD26  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD26  

CELLULAR FUNCTION OF CD26  

DISEASE RELEVANCE OF CD26 AND FUNCTION OF CD26 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD26  

MOLECULAR STRUCTURE OF CD26  

MOLECULAR MASS OF CD26  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Activated T cells 120, 110 kDa 110 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD26  

POST-TRANSLATIONAL MODIFICATION OF CD26   - No information


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD26  
MOLECULECOMMENT
SP-1 For transcription regulation see references 8, 9
AP2 For transcription regulation see references 8, 9
c-myb For transcription regulation see references 8, 9
c-myc For transcription regulation see references 8, 9
Butyrate-responsive element (BRE) For transcription regulation see references 8, 9
HNF-1 For transcription regulation see references 8, 9
NFkB For transcription regulation see references 8, 9

SUBSTRATES FOR CD26  

ENZYMES WHICH MODIFY CD26   - No information

LIGANDS FOR CD26 AND MOLECULES ASSOCIATED WITH CD26  

MOLECULECOMMENT
Adenosine-deaminase Ref 10
Collagen Ref 11
CD45 Ref 12

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD26  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD26   - No information


REAGENTS
CD26-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
202.36 Vilella  
EF5/A3 Kaehne  
EF6/B10 Kaehne/Taeger  
L272 Warner  
BA5 van Agthoven  
2A6 Poppema  
22C3 van Lier / Voorn  

SELECTION OF OTHER CD26-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
4EL1C7 Ref 4  
TII19-4-7 Ref 4  
134-2C2 Ref 4  
TS145    

 
SELECTED REFERENCES ON CD26  

REVIEWS

1. Morimoto, C. and Schlossman, S.F. Immunologist, 2, 4 (1994).

2. Fleischer B CD26: a surface protease involved in T-cell activation. Immunol Today 1994 15:180 PubMed

3. Yaron A,Naider F Proline-dependent structural and biological properties of peptides and proteins. Crit Rev Biochem Mol Biol 1993 28:31 PubMed

PRIMARY CITATIONS

4. Stein, H., Schwarting, R. and Niedobitek, G. In Leucocyte typing IV. (ed. W. Knapp et al.)p.412. Oxford University Press, Oxford. (1989).

5. Hegen M,Niedobitek G,Klein CE,Stein H,Fleischer B The T cell triggering molecule Tp103 is associated with dipeptidyl aminopeptidase IV activity. J Immunol 1990 144:2908 PubMed

6. Tanaka T,Camerini D,Seed B,Torimoto Y,Dang NH,Kameoka J,Dahlberg HN,Schlossman SF,Morimoto C Cloning and functional expression of the T cell activation antigen CD26. J Immunol 1992 149:481 PubMed

7. Hegen M,Camerini D,Fleischer B Function of dipeptidyl peptidase IV (CD26, Tp103) in transfected human T cells. Cell Immunol 1993 146:249 PubMed

8. Abbott CA,Baker E,Sutherland GR,McCaughan GW Genomic organization, exact localization, and tissue expression of the human CD26 (dipeptidyl peptidase IV) gene. Immunogenetics 1994 40:331 PubMed

9. Bohm SK,Gum JR Jr,Erickson RH,Hicks JW,Kim YS Human dipeptidyl peptidase IV gene promoter: tissue-specific regulation from a TATA-less GC-rich sequence characteristic of a housekeeping gene promoter. Biochem J 1995 311:835 PubMed

10. Kameoka J,Tanaka T,Nojima Y,Schlossman SF,Morimoto C Direct association of adenosine deaminase with a T cell activation antigen, CD26. Science 1993 261:466 PubMed

11. Bauvois B A collagen-binding glycoprotein on the surface of mouse fibroblasts is identified as dipeptidyl peptidase IV. Biochem J 1988 252:723 PubMed

12. Torimoto Y,Dang NH,Vivier E,Tanaka T,Schlossman SF,Morimoto C Coassociation of CD26 (dipeptidyl peptidase IV) with CD45 on the surface of human T lymphocytes. J Immunol 1991 147:2514 PubMed

13. Oravecz T,Roderiquez G,Koffi J,Wang J,Ditto M,Bou-Habib DC,Lusso P,Norcross MA CD26 expression correlates with entry, replication and cytopathicity of monocytotropic HIV-1 strains in a T-cell line. Nat Med 1995 1:919 PubMed

14. Dong RP,Kameoka J,Hegen M,Tanaka T,Xu Y,Schlossman SF,Morimoto C Characterization of adenosine deaminase binding to human CD26 on T cells and its biologic role in immune response. J Immunol 1996 156:1349 PubMed

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Modified 10/14/99   mpr@mail.nih.gov