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PROW: CD132
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD132
Author: Kazuo Sugamura
Reviewer: Warren J. Leonard
[GUIDE BAR]

ALTERNATE NAMES FOR CD132  

MAJOR LINKS FOR CD132  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD132  

CELLULAR FUNCTION OF CD132  

DISEASE RELEVANCE OF CD132 AND FUNCTION OF CD132 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD132  

MOLECULAR STRUCTURE OF CD132  

MOLECULAR MASS OF CD132  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
MOLT4 64 kDa    
PHA-stimulated PBL 65-70 kDa    

POST-TRANSCRIPTIONAL MODIFICATION OF CD132   - Unknown

POST-TRANSLATIONAL MODIFICATION OF CD132  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD132   - No information

SUBSTRATES FOR CD132   - No information

ENZYMES WHICH MODIFY CD132   - Jak3 is a candidate

LIGANDS FOR CD132 AND MOLECULES ASSOCIATED WITH CD132  

MOLECULECOMMENT
IL-2 See note 1
IL-4 See note 1
IL-7 See note 1
IL-9 See note 1
IL-15 See note 1
CD25 (IL-2R alpha) High-affinity IL-2 receptor consists of CD25, CD122 and CD132
CD122 (IL-2R beta) High-affinity IL-2 receptor consists of CD25, CD122 and CD132
CD124 (IL-4R alpha) High-affinity type I IL-4 receptor consists of CD124 and CD132*
CD127 (IL-7R) High-affinity IL-7 receptor consists of CD127 and CD132
IL-9R Fully functional IL-9 receptor consists of at least IL-9R and CD132
IL-15R alpha* High-affinity type I IL-15 receptor consists of IL-15R alpha, CD122 and CD132*
Jak3 Jak3 kinase is constitutively associated with CD132 and activated after the stimulation with IL-2, IL-4, IL-7, IL-9 and IL-15*
Jak1 Tyrosine kinase associated with and activated by some of the CD132 receptor complexes*
Syk Tyrosine kinase associated with and activated by some of the CD132 receptor complexes*
lck Tyrosine kinase associated with and activated by some of the CD132 receptor complexes*

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD132  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD132  
REAGENTS
CD132-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
TUGh4 (C-89) Kazuo Sugamura, Sendai  
3B5 (C-96) Jerome Ritz, Boston  
3G11 (C-97) Jerome Ritz, Boston  
AG14C (C-98) Toshiro Shimamura, Kawasaki  
AG43C (C-99) Toshiro Shimamura, Kawasaki  
AG184 (C-100) Toshiro Shimamura, Kawasaki  

SELECTION OF OTHER CD132-SPECIFIC REFERENCE MAB   - No information


 
SELECTED REFERENCES ON CD132  

REVIEWS

1. Leonard WJ The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling. Annu Rev Med 1996 47:229 PubMed

2. Leonard WJ,Shores EW,Love PE Role of the common cytokine receptor gamma chain in cytokine signaling and lymphoid development. Immunol Rev 1995 148:97 ** PubMed

3. Sugamura K,Asao H,Kondo M,Tanaka N,Ishii N,Nakamura M,Takeshita T The common gamma-chain for multiple cytokine receptors. Adv Immunol 1995 59:225 PubMed

4. Sugamura K,Asao H,Kondo M,Tanaka N,Ishii N,Ohbo K,Nakamura M,Takeshita T The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Annu Rev Immunol 1996 14:179 PubMed

PRIMARY CITATIONS

5. Kondo M,Takeshita T,Higuchi M,Nakamura M,Sudo T,Nishikawa S,Sugamura K Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes. Science 1994 263:1453 ** PubMed

6. Kondo M,Takeshita T,Ishii N,Nakamura M,Watanabe S,Arai K,Sugamura K Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science 1993 262:1874 ** PubMed

7. Noguchi M,Nakamura Y,Russell SM,Ziegler SF,Tsang M,Cao X,Leonard WJ Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science 1993 262:1877 ** PubMed

8. Noguchi M,Yi H,Rosenblatt HM,Filipovich AH,Adelstein S,Modi WS,McBride OW,Leonard WJ Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 1993 73:147 ** PubMed

9. Russell SM,Keegan AD,Harada N,Nakamura Y,Noguchi M,Leland P,Friedmann MC,Miyajima A,Puri RK,Paul WE,et al Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science 1993 262:1880 ** PubMed

10. Takeshita T,Asao H,Ohtani K,Ishii N,Kumaki S,Tanaka N,Munakata H,Nakamura M,Sugamura K Cloning of the gamma chain of the human IL-2 receptor. Science 1992 257:379 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov