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PROW: CD22
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PROW and IWHLDA present the GUIDE on:
CD22
Author: Pablo Engel
Reviewer: John Kehrl
Link to additional info in FORUM
[GUIDE BAR]

ALTERNATE NAMES FOR CD22  

MAJOR LINKS FOR CD22  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD22   - No information

CELLULAR FUNCTION OF CD22  

DISEASE RELEVANCE OF CD22 AND FUNCTION OF CD22 IN INTACT ANIMAL Link to additional info in FORUM  


STRUCTURE
MOLECULAR FAMILY FOR CD22  

MOLECULAR STRUCTURE OF CD22  

MOLECULAR MASS OF CD22  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Unspecified 140 kDa 130 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD22  

POST-TRANSLATIONAL MODIFICATION OF CD22  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD22   - No information

SUBSTRATES FOR CD22   - No information

ENZYMES WHICH MODIFY CD22   - No information

LIGANDS FOR CD22 AND MOLECULES ASSOCIATED WITH CD22  

MOLECULECOMMENT
p72sky Tyrosine kinases
p53/56lyn Tyrosine kinases
Phosphatidyl inositol-3 kinase Tyrosine kinases
SHP1 Tyrosine phosphatase
Phospholipase Cgamma1  

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD22  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD22  
REAGENTS
CD22-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
AA2 Funderud  
B-ly2 Poppema  

SELECTION OF OTHER CD22-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
HD39 Dorken et al. 1986  
HB22.7 Engel et al. 1993  

 
SELECTED REFERENCES ON CD22  

REVIEWS

PRIMARY CITATIONS

1. Campbell MA,Klinman NR Phosphotyrosine-dependent association between CD22 and protein tyrosine phosphatase 1C. Eur J Immunol 1995 25:1573 PubMed

2. Doody GM,Justement LB,Delibrias CC,Matthews RJ,Lin J,Thomas ML,Fearon DT A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. Science 1995 269:242 PubMed

3. Dorken B,Moldenhauer G,Pezzutto A,Schwartz R,Feller A,Kiesel S,Nadler LM HD39 (B3), a B lineage-restricted antigen whose cell surface expression is limited to resting and activated human B lymphocytes. J Immunol 1986 136:4470 PubMed

4. Engel P,Nojima Y,Rothstein D,Zhou LJ,Wilson GL,Kehrl JH,Tedder TF The same epitope on CD22 of B lymphocytes mediates the adhesion of erythrocytes, T and B lymphocytes, neutrophils, and monocytes. J Immunol 1993 150:4719 PubMed

5. Engel P,Wagner N,Miller AS,Tedder TF Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand. J Exp Med 1995 181:1581 PubMed

6. Law CL,Torres RM,Sundberg HA,Parkhouse RM,Brannan CI,Copeland NG,Jenkins NA,Clark EA Organization of the murine Cd22 locus. Mapping to chromosome 7 and characterization of two alleles. J Immunol 1993 151:175 PubMed

7. Leprince C,Draves KE,Geahlen RL,Ledbetter JA,Clark EA CD22 associates with the human surface IgM-B-cell antigen receptor complex. Proc Natl Acad Sci U S A 1993 90:3236 PubMed

8. Nitschke L,Carsetti R,Ocker B,Kohler G,Lamers MC CD22 is a negative regulator of B-cell receptor signalling. Curr Biol 1997 7:133 PubMed

9. Powell LD,Varki A I-type lectins. J Biol Chem 1995 270:14243 PubMed

10. Stamenkovic I,Seed B The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion. Nature 1990 345:74 PubMed

11. Tuscano JM,Engel P,Tedder TF,Agarwal A,Kehrl JH Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22. Eur J Immunol 1996 26:1246 PubMed

12. Wilson GL,Fox CH,Fauci AS,Kehrl JH cDNA cloning of the B cell membrane protein CD22: a mediator of B-B cell interactions. J Exp Med 1991 173:137 PubMed

13. Wilson GL,Najfeld V,Kozlow E,Menniger J,Ward D,Kehrl JH Genomic structure and chromosomal mapping of the human CD22 gene. J Immunol 1993 150:5013 PubMed

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Modified 10/14/99   mpr@mail.nih.gov