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PROW: CD80
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD80
Author: Margaret Jones
Reviewer: Jeffrey A. Bluestone
[GUIDE BAR]

ALTERNATE NAMES FOR CD80  

MAJOR LINKS FOR CD80  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD80   - No information

CELLULAR FUNCTION OF CD80  

DISEASE RELEVANCE OF CD80 AND FUNCTION OF CD80 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD80  

MOLECULAR STRUCTURE OF CD80  

MOLECULAR MASS OF CD80  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
B cells 60 kDa (Immunoprecipitation)   Highly glycosylated so broad MW**

POST-TRANSCRIPTIONAL MODIFICATION OF CD80  

POST-TRANSLATIONAL MODIFICATION OF CD80  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD80   - No information

SUBSTRATES FOR CD80   - No information

ENZYMES WHICH MODIFY CD80   - No information

LIGANDS FOR CD80 AND MOLECULES ASSOCIATED WITH CD80  

MOLECULECOMMENT
CD28 Activation of T cells
CD152 (CTLA4) Inhibits T cell activation

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD80  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD80   - No information


REAGENTS
CD80-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
CD80.1 2D10.4 Olive  
CD80.2 MAB 104 A van Agthoven, Marseilles, France  
CD80.3 Dae-1 W Zeijlemaker, Amsterdam, Netherlands  

SELECTION OF OTHER CD80-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
133 Leucocyte Typing V, 1996  
B7-g Leucocyte Typing V, 1996  
BB1 Leucocyte Typing V, 1996  
49 Leucocyte Typing V, 1996  
L307 Leucocyte Typing V, 1996  

 
SELECTED REFERENCES ON CD80  

REVIEWS

PRIMARY CITATIONS

1. Engel, P., Wagner, N. and Tedder, T.F. In Leucocyte Typing V ed. Schlossman et al p 682-684 (1996)

2. Freedman AS,Freeman G,Horowitz JC,Daley J,Nadler LM B7, a B-cell-restricted antigen that identifies preactivated B cells. J Immunol 1987 139:3260 PubMed

3. Freeman GJ,Disteche CM,Gribben JG,Adler DA,Freedman AS,Dougery J,Nadler LM The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21. Blood 1992 79:489 PubMed

4. Freeman GJ,Freedman AS,Segil JM,Lee G,Whitman JF,Nadler LM B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J Immunol 1989 143:2714 PubMed

5. Freeman GJ,Gray GS,Gimmi CD,Lombard DB,Zhou LJ,White M,Fingeroth JD,Gribben JG,Nadler LM Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. J Exp Med 1991 174:625 PubMed

6. Linsley PS,Bradshaw J,Greene J,Peach R,Bennett KL,Mittler RS Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity 1996 4:535 PubMed

7. Linsley PS,Brady W,Urnes M,Grosmaire LS,Damle NK,Ledbetter JA CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med 1991 174:561 PubMed

8. Linsley PS,Clark EA,Ledbetter JA T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc Natl Acad Sci U S A 1990 87:5031 PubMed

9. Yokochi T,Holly RD,Clark EA B lymphoblast antigen (BB-1) expressed on Epstein-Barr virus-activated B cell blasts, B lymphoblastoid cell lines, and Burkitt's lymphomas. J Immunol 1982 128:823 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov