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PROW: CD52
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD52
Author: Geoff Hale
Reviewer: Martin R. Hadam
[GUIDE BAR]

ALTERNATE NAMES FOR CD52  

MAJOR LINKS FOR CD52  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD52   - No information

CELLULAR FUNCTION OF CD52   - No information

DISEASE RELEVANCE OF CD52 AND FUNCTION OF CD52 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD52  

MOLECULAR STRUCTURE OF CD52  

MOLECULAR MASS OF CD52  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Human lymphocytes 25-29 kDa 25-29 kDa  
Human spermatozoa   25-29 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD52  

POST-TRANSLATIONAL MODIFICATION OF CD52  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD52   - No information

SUBSTRATES FOR CD52   - No information

ENZYMES WHICH MODIFY CD52   - No information

LIGANDS FOR CD52 AND MOLECULES ASSOCIATED WITH CD52   - No information


EXPRESSION
MAIN CELLULAR EXPRESSION OF CD52  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD52  
REAGENTS
CD52-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
HI-186 (6wT-057) De-Cheng Shen, Tianjin*  
CF1D12 (6wNL-128) Martin R Hadam, Hannover  

SELECTION OF OTHER CD52-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
O97 Valentin et al. 1992  
YTH 66.9 (CAMPATH-1M) Hale et al. 1990  
YTH 34.5 Hale et al. 1990  
YTH 361.10 Hale et al. 1990  

 
SELECTED REFERENCES ON CD52  

REVIEWS

1. Hale G,Phillips JM Clinical trials with CAMPATH-I and other monoclonal antibodies. Biochem Soc Trans 1995 23:1057 PubMed

2. Hale G,Waldmann H CAMPATH-1 monoclonal antibodies in bone marrow transplantation. J Hematother 1994 3:15 PubMed

3. Hale G,Xia MQ,Tighe HP,Dyer MJ,Waldmann H The CAMPATH-1 antigen (CDw52). Tissue Antigens 1990 35:118 PubMed

4. Kirchhoff C,Hale G Cell-to-cell transfer of glycosylphosphatidylinositol-anchored membrane proteins during sperm maturation. Mol Hum Reprod 1996 2:177 PubMed

PRIMARY CITATIONS

5. Hale G,Rye PD,Warford A,Lauder I,Brito-Babapulle A The glycosylphosphatidylinositol-anchored lymphocyte antigen CDw52 is associated with the epididymal maturation of human spermatozoa. J Reprod Immunol 1993 23:189 PubMed

6. Kirchhoff, C. Krull, N., Pera, I., and Ivell, R. 1992. Mol. Repr. Dev. 34:11-15.

7. Riechmann L,Clark M,Waldmann H,Winter G Reshaping human antibodies for therapy. Nature 1988 332:323 PubMed

8. Treumann A,Lifely MR,Schneider P,Ferguson MA Primary structure of CD52. J Biol Chem 1995 270:6088 PubMed

9. Valentin H,Gelin C,Coulombel L,Zoccola D,Morizet J,Bernard A The distribution of the CDW52 molecule on blood cells and characterization of its involvement in T cell activation. Transplantation 1992 54:97 PubMed

10. Xia MQ,Hale G,Lifely MR,Ferguson MA,Campbell D,Packman L,Waldmann H Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol- anchored glycoprotein which is an exceptionally good target for complement lysis. Biochem J 1993 293:633 PubMed

11. Xia MQ,Tone M,Packman L,Hale G,Waldmann H Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone. Eur J Immunol 1991 21:1677 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov