Science Gateway > Resources > Cluster of Differentiation Index

PROW presents the FAMILY:
Authors: Eric O. Long, Marco Colonna, Lewis L. Lanier
Reviewer: Miguel Lopez-Botet


Killer cell immunoglobulin (Ig)-like receptors (KIR), also called killer cell inhibitory receptors, are glycoproteins expressed in natural killer (NK) cells and some T cells. The KIR family is estimated to include about 11 genes. Some members of the KIR family bind specifically to certain HLA class I allotypes. Ligation of such KIR by HLA class I molecules on target cells results in inhibition of the NK or T cell cytotoxic activity. The KIR family is subdivided into two subfamilies based on structure. Some KIR members have two Ig domains (KIR2D), others have three Ig domains (KIR3D). KIR members vary also in the length of the cytoplasmic tails. Typically, KIR with a long cytoplasmic tail (L) deliver an inhibitory signal, whereas KIR with a short cytoplasmic tail (S) can activate NK or T cell responses

  • KIR2DL subfamily
  • KIR2DS subfamily
  • KIR3DL subfamily
  • KIR3DS subfamily


    SHP-1  The long cytoplasmic tails bind the tyrosine phosphatase SHP-1 through two tyrosine-phosphorylated ITIM sequences [I/V]xYxxL (Burshtyn et al. 1996; Olcese et al. 1996; Campbell et al. 1996; Fry et al. 1996; Burshtyn et al. 1997)
    DAP12 KIR isoforms with short cytoplasmic tails associate with a disulfide linked dimer of 14 kDa phosphoproteins called DAP12. DAP12 is also known as KARAP (Killer activating receptor associated protein)*(Olcese et al. 1997; Lanier et al. 1998)

  • cDNA Information



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    * indicates ammended by reviewer, ** indicates added by reviewer

    Modified 10/15/99