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PROW: CD11b
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD11b
Author: Nancy Hogg
Reviewer: M. Amin Arnaout
[GUIDE BAR]

ALTERNATE NAMES FOR CD11b  

MAJOR LINKS FOR CD11b  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD11b   - No information

CELLULAR FUNCTION OF CD11b  

DISEASE RELEVANCE OF CD11b AND FUNCTION OF CD11b IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD11b  

MOLECULAR STRUCTURE OF CD11b  

MOLECULAR MASS OF CD11b  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Leukocytes 165 kDa 170 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD11b  

POST-TRANSLATIONAL MODIFICATION OF CD11b  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD11b  
MOLECULECOMMENT
PU.1 **
Sp1 **
MS-2 **

SUBSTRATES FOR CD11b   - No information

ENZYMES WHICH MODIFY CD11b   - No information

LIGANDS FOR CD11b AND MOLECULES ASSOCIATED WITH CD11b  

MOLECULECOMMENT
iC3b *
Fibrinogen  
Factor X  
FcR II Cis interactions (see Petty and Todd, 1996)
FcR III Cis interactions (see Petty and Todd, 1996)
uPAR Cis interactions (see Petty and Todd, 1996)
CD14 Cis interactions (see Petty and Todd, 1996)
ICAM-1 (intercellular adhesion molecule 1) (CD54)  
ICAM-2 (intercellular adhesion molecule 2) (CD102) **
ICAM-4 (intercellular adhesion molecule 4) **
Heparin  
Haptoglobin  
Kininogen **
CD23 **
LPS/LPB (complex of LPS and LPS binding protein)  
Neutrophil inhibitory factor from Ancylostoma C. Microbial protein
Filamentous hemagglutinin form Bordetella P Microbial protein
gp63 from Leishmenia D. Microbial protein
WI-1 antigen from Blastomyces D. Microbial protein

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD11b  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD11b   - No information


REAGENTS
CD11b-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
LT-11 A Filatov  
Bear 1 A van Agthoven  
X5 J H Peters  
2H3 L Boumsell  
MEM -170 V Horejsi  
MEM -174 V Horejsi  

SELECTION OF OTHER CD11b-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
44 ATCC/R Todd Known to be specific for I domain of CD11b
ICRF44(formerly 44) N Hogg Known to be specific for I domain of CD11b
LPM19c K Pulford Known to be specific for I domain of CD11b
Mn41 J Buyon/MS Diamond et al. 1993  
107 MA Arnaout** Known to be specific for I domain of CD11b

 
SELECTED REFERENCES ON CD11b  

REVIEWS

1. Arnaout MA Leukocyte adhesion molecules deficiency: its structural basis, pathophysiology and implications for modulating the inflammatory response. Immunol Rev 1990 114:145 ** PubMed

2. Petty HR,Todd RF 3d Integrins as promiscuous signal transduction devices. Immunol Today 1996 17:209 PubMed

3. Springer TA Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994 76:301 PubMed

4. Stewart M,Thiel M,Hogg N Leukocyte integrins. Curr Opin Cell Biol 1995 7:690 PubMed

PRIMARY CITATIONS

5. Arnaout MA,Gupta SK,Pierce MW,Tenen DG Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mo1 (complement receptor type 3). J Cell Biol 1988 106:2153 ** PubMed

6. Corbi AL,Kishimoto TK,Miller LJ,Springer TA The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B. J Biol Chem 1988 263:12403 PubMed

7. Coxon A,Rieu P,Barkalow FJ,Askari S,Sharpe AH,von Andrian UH,Arnaout MA,Mayadas TN A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity 1996 5:653 ** PubMed

8. Diamond MS,Garcia-Aguilar J,Bickford JK,Corbi AL,Springer TA The I domain is a major recognition site on the leukocyte integrin Mac- 1 (CD11b/CD18) for four distinct adhesion ligands. J Cell Biol 1993 120:1031 PubMed

9. Lee JO,Rieu P,Arnaout MA,Liddington R Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18). Cell 1995 80:631 PubMed

10. Michishita M,Videm V,Arnaout MA A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand binding. Cell 1993 72:857 PubMed

11. Springer TA Folding of the N-terminal, ligand-binding region of integrin alpha- subunits into a beta-propeller domain. Proc Natl Acad Sci U S A 1997 94:65 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/15/99   mpr@mail.nih.gov