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PROW: CD11a
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD11a
Authors: Nancy Hogg; Eric Martz
Reviewer:
Reviewer became coauthor
[GUIDE BAR]

ALTERNATE NAMES FOR CD11a  

MAJOR LINKS FOR CD11a  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD11a  

CELLULAR FUNCTION OF CD11a  

DISEASE RELEVANCE OF CD11a AND FUNCTION OF CD11a IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD11a  

MOLECULAR STRUCTURE OF CD11a  

MOLECULAR MASS OF CD11a  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Leukocytes 170kDa 180kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD11a   - No information

POST-TRANSLATIONAL MODIFICATION OF CD11a  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD11a   - No information

SUBSTRATES FOR CD11a   - No information

ENZYMES WHICH MODIFY CD11a   - No information

LIGANDS FOR CD11a AND MOLECULES ASSOCIATED WITH CD11a  


EXPRESSION
MAIN CELLULAR EXPRESSION OF CD11a  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD11a  
REAGENTS
CD11a-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
CD11a-5E4 W Knapp Reacts with isolated I domain of CD11a
CD11a-6B7 W Knapp Reacts with isolated I domain of CD11a
AZN-L20 Y van Kooyk  
AZN-L21 Y van Kooyk  
BL5 J Brochier  
BU85 DL Hardie  

SELECTION OF OTHER CD11a-SPECIFIC REFERENCE MAB  


 
SELECTED REFERENCES ON CD11a  

REVIEWS

1. Bergelson JM and Hemler ME. Integrin-ligand binding. Do integrins use a 'MIDAS touch' to grasp an Asp? Curr. Biol. 1995 5:615 PubMed

2. Hogg, N., R. C. Landis, P. A. Bates, P. Stanley, A. M. Randi. 1994, Trends in Cell Biol. 4:379-382

3. Lub M, van Kooyk Y and Figdor CG. Ins and outs of LFA-1. Immunol. Today 1995 16:479 PubMed

4. Martz, E. Leukocyte function-associated antigen one (LFA-1). 1997. Encyclopedia of Immunology, 2nd ed., Ivan M. Roitt and Peter J. Delves, eds. Academic Press, London, in press.

5. Parsons JT. Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins. Curr. Opin. Cell Biol. 1996 8:146 PubMed

6. Petty HR and Todd RF 3d. Integrins as promiscuous signal transduction devices. Immunol. Today 1996 17:209 PubMed

7. Sanchez-Mateos P, Cabanas C and Sanchez-Madrid F. Regulation of integrin function. Semin. Cancer Biol. 1996 7:99 PubMed

8. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994 76:301 PubMed

9. Stewart M, Thiel M and Hogg N. Leukocyte integrins. Curr. Opin. Cell Biol. 1995 7:690 PubMed

PRIMARY CITATIONS

10. Dustin ML and Springer TA. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 1989 341:619 PubMed

11. Larson RS, Corbi AL, Berman L and Springer T. Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily. J. Cell Biol. 1989 108:703 PubMed

12. Lee JO, Bankston LA, Arnaout MA and Liddington RC. Two conformations of the integrin A-domain (I-domain): a pathway for activation? Structure 1995 3:1333 PubMed

13. Qu A and Leahy DJ. Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin. Proc. Natl. Acad. Sci. U.S.A. 1995 92:10277 PubMed

14. Qu A and Leahy DJ. The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin. Structure 1996 4:931 PubMed

15. Schmits R, Kundig TM, Baker DM, Shumaker G, Simard JJ, Duncan G, Wakeham A, Shahinian A, van der Heiden A, Bachmann MF, Ohashi PS, Mak TW and Hickstein DD. LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J. Exp. Med. 1996 183:1415 PubMed

16. Springer TA. Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain. Proc. Natl. Acad. Sci. U.S.A. 1997 94:65 PubMed

WWW RESOURCES

CD11a from NCBI Entrez
CD18 from NCBI Entrez
Martz web site on LFA-1


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov