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PROW: CD142
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD142
Author: James H. Morrissey
Reviewer: Steven D. Carson
[GUIDE BAR]

ALTERNATE NAMES FOR CD142  

MAJOR LINKS FOR CD142  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD142  

CELLULAR FUNCTION OF CD142  

DISEASE RELEVANCE OF CD142 AND FUNCTION OF CD142 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD142  

MOLECULAR STRUCTURE OF CD142  

MOLECULAR MASS OF CD142  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Many cell types 45-47 kDa 45-47 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD142  

POST-TRANSLATIONAL MODIFICATION OF CD142  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD142  
MOLECULECOMMENT
AP-1  
c-Rel/p65  
Egr-1  
Sp1  
Ets  

SUBSTRATES FOR CD142  

MOLECULECOMMENT
Factor X Activated via limited proteolysis by the cell-surface complex of CD142 and factor VIIa
Factor IX Activated via limited proteolysis by the cell-surface complex of CD142 and factor VIIa
Factor VII Activated via limited proteolysis by the cell-surface complex of CD142 and factor VIIa

ENZYMES WHICH MODIFY CD142   - No information

LIGANDS FOR CD142 AND MOLECULES ASSOCIATED WITH CD142  

MOLECULECOMMENT
Factor VIIa  
Factor Xa/TFPI Binds to (and inhibits) the complex of CD142 and factor VIIa

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD142  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD142  
REAGENTS
CD142-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
MTFH-1 (E131) James H. Morrissey, Oklahoma City, USA  
TF9-5B7 (E132) Morrissey JH et al. 1988  
TF9-10H10 (E133) Morrissey JH et al. 1988  
HTF-K4 (E134) Shin Nakamura, Inuyama, Japan  
HTF-K14 (E135) Shin Nakamura, Inuyama, Japan  
HTF-K108 (E034, E136) Shin Nakamura, Inuyama, Japan  
HTF1-7B8 (E016) Carson SD et al. 1987  
TF8-5G9 (E138) Morrissey JH et al. 1988  
TF10-1D10 (E139) Thomas S. Edgington, La Jolla, USA  
III-D8 (E140) Albrecht S et al. 1992  
V-D8 (E141) Albrecht S et al. 1992  
VI-C7 (E032) Albrecht S et al. 1992  

SELECTION OF OTHER CD142-SPECIFIC REFERENCE MAB   - No information


 
SELECTED REFERENCES ON CD142  

REVIEWS

1. Carson SD,Brozna JP The role of tissue factor in the production of thrombin. Blood Coagul Fibrinolysis 1993 4:281 PubMed

2. Mackman N Regulation of the tissue factor gene. FASEB J 1995 9:883 PubMed

PRIMARY CITATIONS

3. Albrecht S,Luther T,Grossmann H,Flossel C,Kotzsch M,Muller M An ELISA for tissue factor using monoclonal antibodies. Blood Coagul Fibrinolysis 1992 3:263 PubMed

4. Carson SD,Ross SE,Bach R,Guha A An inhibitory monoclonal antibody against human tissue factor. Blood 1987 70:490 PubMed

5. Morrissey JH,Fair DS,Edgington TS Monoclonal antibody analysis of purified and cell-associated tissue factor. Thromb Res 1988 52:247 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov