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PROW: CD107b
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD107b
Author: Masja de Haas
Reviewer: Minoru Fukuda
[GUIDE BAR]

ALTERNATE NAMES FOR CD107b  

MAJOR LINKS FOR CD107b  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD107b   - No information

CELLULAR FUNCTION OF CD107b   - No information

DISEASE RELEVANCE OF CD107b AND FUNCTION OF CD107b IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD107b  

MOLECULAR STRUCTURE OF CD107b  

MOLECULAR MASS OF CD107b  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Platelets 100-120    

POST-TRANSCRIPTIONAL MODIFICATION OF CD107b   - No information

POST-TRANSLATIONAL MODIFICATION OF CD107b  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD107b  
MOLECULECOMMENT
SP1 Potential SP1 and AP-1 binding sites present in the 5'-flanking region (-172 to -20bp)
AP-1 Potential SP1 and AP-1 binding sites present in the 5'-flanking region (-172 to -20bp)
KpnI A KpnI repeat sequence upstream of the promoter sequence might regulate expression (Sawada et al. 1993)

SUBSTRATES FOR CD107b   - No information

ENZYMES WHICH MODIFY CD107b   - No information

LIGANDS FOR CD107b AND MOLECULES ASSOCIATED WITH CD107b   - No information


EXPRESSION
MAIN CELLULAR EXPRESSION OF CD107b  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD107b  
REAGENTS
CD107b-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP   - None

SELECTION OF OTHER CD107b-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
H4B4 JT August, Baltimore  
CD3 M Fukuda, La Jolla  

 
SELECTED REFERENCES ON CD107b  

REVIEWS

1. Fukuda M Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking. J Biol Chem 1991 266:21327 PubMed

PRIMARY CITATIONS

2. Dahlgren C,Carlsson SR,Karlsson A,Lundqvist H,Sjolin C The lysosomal membrane glycoproteins Lamp-1 and Lamp-2 are present in mobilizable organelles, but are absent from the azurophil granules of human neutrophils. Biochem J 1995 311:667 PubMed

3. Lippincott-Schwartz J,Fambrough DM Lysosomal membrane dynamics: structure and interorganellar movement of a major lysosomal membrane glycoprotein. J Cell Biol 1986 102:1593 PubMed

4. Sawada R,Jardine KA,Fukuda M The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes. J Biol Chem 1993 268:9014 * PubMed

5. Silverstein RL,Febbraio M Identification of lysosome-associated membrane protein-2 as an activation-dependent platelet surface glycoprotein. Blood 1992 80:1470 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov