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PROW: CD42d
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD42d
Authors: Masja de Haas; Albert von dem Borne
Reviewer: Kenneth J. Clemetson
[GUIDE BAR]

ALTERNATE NAMES FOR CD42d  

MAJOR LINKS FOR CD42d  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD42d  

CELLULAR FUNCTION OF CD42d  

DISEASE RELEVANCE OF CD42d AND FUNCTION OF CD42d IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD42d  

MOLECULAR STRUCTURE OF CD42d  

MOLECULAR MASS OF CD42d  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Platelets 82 kDa 82 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD42d   - No information

POST-TRANSLATIONAL MODIFICATION OF CD42d  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD42d  
MOLECULECOMMENT
GATA-1  
Ets  

SUBSTRATES FOR CD42d   - No information

ENZYMES WHICH MODIFY CD42d  

MOLECULECOMMENT
Thrombin  

LIGANDS FOR CD42d AND MOLECULES ASSOCIATED WITH CD42d  

MOLECULECOMMENT
CD42a Note 1
CD42b Note 1
CD42c Note 1

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD42d  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD42d  
REAGENTS
CD42d-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
V3 (P-36) Lanza, Strasbourg  
NaM28-8C12 (P-55) Blanchard, Nantes  

SELECTION OF OTHER CD42d-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
CLB-SW16 Von dem Borne, Amsterdam  

 
SELECTED REFERENCES ON CD42d  

REVIEWS

PRIMARY CITATIONS

1. Clemetson KJ, McGregor JL, James E, Dechavanne M and Luscher EF. Characterization of the platelet membrane glycoprotein abnormalities in Bernard-Soulier syndrome and comparison with normal by surface-labeling techniques and high-resolution two-dimensional gel electrophoresis. J. Clin. Invest. 1982 70:304 ** PubMed

2. Dong JF, Sae-Tung G and Lopez JA. Role of glycoprotein V in the formation of the platelet high-affinity thrombin-binding site. Blood 1997 89:4355 ** PubMed

3. Hickey MJ, Hagen FS, Yagi M and Roth GJ. Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins. Proc. Natl. Acad. Sci. U.S.A. 1993 90:8327 PubMed

4. Lanza F, Morales M, de La Salle C, Cazenave JP, Clemetson KJ, Shimomura T and Phillips DR. Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation. J. Biol. Chem. 1993 268:20801 PubMed

5. Lopez JA, Leung B, Reynolds CC, Li CQ and Fox JE. Efficient plasma membrane expression of a functional platelet glycoprotein Ib-IX complex requires the presence of its three subunits. J. Biol. Chem. 1992 267:12851 PubMed

6. Modderman PW, Admiraal LG, Sonnenberg A and von dem Borne AE. Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane. J. Biol. Chem. 1992 267:364 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov