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PROW: CD66d
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD66d
Authors: Keith Skubitz; Fritz Grunert; Peter Jantscheff; Motomu Kuroki; Amy Skubitz
Reviewer:
Diverse coauthors in lieu of reviewer
Link to additional info in FORUM
[GUIDE BAR]

ALTERNATE NAMES FOR CD66d  

MAJOR LINKS FOR CD66d  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD66d   - Unclear, see ligands

CELLULAR FUNCTION OF CD66d  

DISEASE RELEVANCE OF CD66d AND FUNCTION OF CD66d IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD66d  

MOLECULAR STRUCTURE OF CD66d  

MOLECULAR MASS OF CD66d  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Granulocytes   35 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD66d  

POST-TRANSLATIONAL MODIFICATION OF CD66d  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD66d   - No information

SUBSTRATES FOR CD66d   - No information

ENZYMES WHICH MODIFY CD66d   - No information

LIGANDS FOR CD66d AND MOLECULES ASSOCIATED WITH CD66d Link to additional info in FORUM  

MOLECULECOMMENT
None known No homotypic or heterotypic adhesion has been identified

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD66d   - Granulocytes


 
AUTHOR'S ADDITIONAL INSIGHTS ON CD66d  
REAGENTS
CD66d-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP   - See reference mAb

SELECTION OF OTHER CD66d-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
COL-1 Dr. Jeffrey Schlom, Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892  

 
SELECTED REFERENCES ON CD66d  

REVIEWS

PRIMARY CITATIONS

1. Thompson JA,Grunert F,Zimmermann W Carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J Clin Lab Anal 1991 5:344 PubMed

2. Kuroki M,Arakawa F,Matsuo Y,Oikawa S,Misumi Y,Nakazato H,Matsuoka Y Molecular cloning of nonspecific cross-reacting antigens in human granulocytes. J Biol Chem 1991 266:11810 PubMed

3. Nagel G,Grunert F,Kuijpers TW,Watt SM,Thompson J,Zimmermann W Genomic organization, splice variants and expression of CGM1, a CD66- related member of the carcinoembryonic antigen gene family. Eur J Biochem 1993 214:27 PubMed

4. Skubitz KM,Campbell KD,Ahmed K,Skubitz AP CD66 family members are associated with tyrosine kinase activity in human neutrophils. J Immunol 1995 155:5382 PubMed

5. Skubitz KM,Campbell KD,Skubitz AP CD66a, CD66b, CD66c, and CD66d each independently stimulate neutrophils. J Leukoc Biol 1996 60:106 PubMed

6. Chen T,Gotschlich EC CGM1a antigen of neutrophils, a receptor of gonococcal opacity proteins. Proc Natl Acad Sci U S A 1996 93:14851 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov