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PROW: CD31
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD31
Author: William A. Muller
Reviewer: Peter J. Newman
Link to additional info in FORUM
[GUIDE BAR]

ALTERNATE NAMES FOR CD31  

MAJOR LINKS FOR CD31  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD31  

CELLULAR FUNCTION OF CD31  

DISEASE RELEVANCE OF CD31 AND FUNCTION OF CD31 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD31  

MOLECULAR STRUCTURE OF CD31  

MOLECULAR MASS OF CD31  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
All 130-140 kDa 130-140 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD31  

POST-TRANSLATIONAL MODIFICATION OF CD31  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD31  
MOLECULECOMMENT
TATA-less promoter Transcription appears controlled in part by GATA element

SUBSTRATES FOR CD31   - N/A

ENZYMES WHICH MODIFY CD31  

MOLECULECOMMENT
Undefined serine kinase - perhaps PKC *
Tyrosine kinase Src *

LIGANDS FOR CD31 AND MOLECULES ASSOCIATED WITH CD31 Link to additional info in FORUM  

MOLECULECOMMENT
Platelet endothelial cell adhesion 1(PECAM-1) (CD31) Homophilic interaction
Heparan sulfate glycosaminoglycan chains (GAGs) Binding inferred, but controversial*
Alpha v/beta 3 integrin Direct binding reported, but controversial
SHP-2 Docks on cytoplasmic tail

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD31  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD31  
REAGENTS
CD31-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
4G6 (A020) D Kawahara  
158-2B3 (A040) R Vilella  
CD31-1B5 (A081) W Knapp  
CD31-7E4 (A082) W Knapp  
hec7 (A083) W Muller  
IP28 (A096) Bessusan  

SELECTION OF OTHER CD31-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
P1.1 P Newman  
P1.2 P Newman  
P1.3 P Newman  
WM59 M Berndt  
JC70A Dako Corp  

 
SELECTED REFERENCES ON CD31  

REVIEWS

1. DeLisser HM, Newman PJ and Albelda SM. Molecular and functional aspects of PECAM-1/CD31. Immunol. Today 1994 15:490 PubMed

2. Muller, W.A. 1995. Trends in Cardiovasc. Med. 5:15-20.

3. Newman PJ. The biology of PECAM-1. J. Clin. Invest. 1997 99:3 ** PubMed

PRIMARY CITATIONS

4. Baldwin HS, Shen HM, Yan HC, DeLisser HM, Chung A, Mickanin C, Trask T, Kirschbaum NE, Newman PJ, Albelda SM and et al. Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development. Development 1994 120:2539 PubMed

5. Berman ME and Muller WA. Ligation of platelet/endothelial cell adhesion molecule 1 (PECAM-1/CD31) on monocytes and neutrophils increases binding capacity of leukocyte CR3 (CD11b/CD18). J. Immunol. 1995 154:299 PubMed

6. DeLisser HM, Christofidou-Solomidou M, Strieter RM, Burdick MD, Robinson CS, Wexler RS, Kerr JS, Garlanda C, Merwin JR, Madri JA and Albelda SM. Involvement of endothelial PECAM-1/CD31 in angiogenesis. Am. J. Pathol. 1997 151:671 PubMed

7. Gumina RJ, Kirschbaum NE, Piotrowski K and Newman PJ. Characterization of the human platelet/endothelial cell adhesion molecule-1 promoter: identification of a GATA-2 binding element required for optimal transcriptional activity. Blood 1997 89:1260 ** PubMed

8. Jackson DE, Ward CM, Wang R and Newman PJ. The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet aggregation. Evidence for a mechanistic link between PECAM-1- and integrin-mediated cellular signaling. J. Biol. Chem. 1997 272:6986 ** PubMed

9. Kirschbaum NE, Gumina RJ and Newman PJ. Organization of the gene for human platelet/endothelial cell adhesion molecule-1 shows alternatively spliced isoforms and a functionally complex cytoplasmic domain. Blood 1994 84:4028 PubMed

10. Liao F, Ali J, Greene T and Muller WA. Soluble domain 1 of platelet-endothelial cell adhesion molecule (PECAM) is sufficient to block transendothelial migration in vitro and in vivo. J. Exp. Med. 1997 185:1349 PubMed

11. Liao F, Huynh HK, Eiroa A, Greene T, Polizzi E and Muller WA. Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1. J. Exp. Med. 1995 182:1337 PubMed

12. Muller WA, Ratti CM, McDonnell SL and Cohn ZA. A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions. J. Exp. Med. 1989 170:399 PubMed

13. Muller WA, Weigl SA, Deng X and Phillips DM. PECAM-1 is required for transendothelial migration of leukocytes. J. Exp. Med. 1993 178:449 PubMed

14. Newman PJ, Berndt MC, Gorski J, White GC 2d, Lyman S, Paddock C and Muller WA. PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science 1990 247:1219 PubMed

15. Newman PJ, Hillery CA, Albrecht R, Parise LV, Berndt MC, Mazurov AV, Dunlop LC, Zhang J and Rittenhouse SE. Activation-dependent changes in human platelet PECAM-1: phosphorylation, cytoskeletal association, and surface membrane redistribution. J. Cell Biol. 1992 119:239 PubMed

16. Simmons DL, Walker C, Power C and Pigott R. Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen. J. Exp. Med. 1990 171:2147 PubMed

17. Stockinger H, Gadd SJ, Eher R, Majdic O, Schreiber W, Kasinrerk W, Strass B, Schnabl E and Knapp W. Molecular characterization and functional analysis of the leukocyte surface protein CD31. J. Immunol. 1990 145:3889 PubMed

18. Sun QH, DeLisser HM, Zukowski MM, Paddock C, Albelda SM and Newman PJ. Individually distinct Ig homology domains in PECAM-1 regulate homophilic binding and modulate receptor affinity. J. Biol. Chem. 1996 271:11090 PubMed

19. Tanaka Y, Albelda SM, Horgan KJ, van Seventer GA, Shimizu Y, Newman W, Hallam J, Newman PJ, Buck CA and Shaw S. CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion. J. Exp. Med. 1992 176:245 PubMed

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* indicates ammended by reviewer, ** indicates added by reviewer

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Modified 11/16/99   mpr@mail.nih.gov