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PROW: CD89
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PROW and IWHLDA present the GUIDE on:
CD89
Authors: Hiromi Kubagawa; Max D. Cooper
Reviewer: Jan G. van de Winkel
[GUIDE BAR]

ALTERNATE NAMES FOR CD89  

MAJOR LINKS FOR CD89  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD89  

CELLULAR FUNCTION OF CD89  

DISEASE RELEVANCE OF CD89 AND FUNCTION OF CD89 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD89  

MOLECULAR STRUCTURE OF CD89  

MOLECULAR MASS OF CD89  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Monocyte 45-70 kDa 45-70 kDa  
Neutrophil 55-75 kDa 55-75 kDa  
Eosinophil 70-100 kDa 70-100 kDa  
Alveolar macrophages 50-65 kDa 50-65 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD89  

POST-TRANSLATIONAL MODIFICATION OF CD89   - Glycosylation


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD89   - Unknown

SUBSTRATES FOR CD89   - N/A

ENZYMES WHICH MODIFY CD89   - N/A

LIGANDS FOR CD89 AND MOLECULES ASSOCIATED WITH CD89  

MOLECULECOMMENT
Common Fc receptor gamma chain Serves as transducing unit
IgA1 Ligand
IgA2 Ligand

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD89  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD89  
REAGENTS
CD89-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP   - None

SELECTION OF OTHER CD89-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
A3 Monteiro RC et al.  
A59 Monteiro RC et al.  
A62 Monteiro RC et al.  
A77 Monteiro RC et al. 1992  
My43 Shen L et al. 1989  

 
SELECTED REFERENCES ON CD89  

REVIEWS

1. Kerr MA The structure and function of human IgA. Biochem J 1990 271:285 PubMed

2. Shen L Receptors for IgA on phagocytic cells. Immunol Res 1992 11:273 PubMed

3. Morton HC,van Egmond M,van de Winkel JG Structure and function of human IgA Fc receptors (Fc alpha R). Crit Rev Immunol 1996 16:423 ** PubMed

PRIMARY CITATIONS

4. Shen L,Lasser R,Fanger MW My 43, a monoclonal antibody that reacts with human myeloid cells inhibits monocyte IgA binding and triggers function. J Immunol 1989 143:4117 PubMed

5. Monteiro RC,Kubagawa H,Cooper MD Cellular distribution, regulation, and biochemical nature of an Fc alpha receptor in humans. J Exp Med 1990 171:597 PubMed

6. Maliszewski CR,March CJ,Schoenborn MA,Gimpel S,Shen L Expression cloning of a human Fc receptor for IgA. J Exp Med 1990 172:1665 PubMed

7. Monteiro RC,Cooper MD,Kubagawa H Molecular heterogeneity of Fc alpha receptors detected by receptor- specific monoclonal antibodies. J Immunol 1992 148:1764 PubMed

8. Pfefferkorn LC,Yeaman GR Association of IgA-Fc receptors (Fc alpha R) with Fc epsilon RI gamma 2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of gamma 2. J Immunol 1994 153:3228 PubMed

9. Morton HC,van den Herik-Oudijk IE,Vossebeld P,Snijders A,Verhoeven AJ,Capel PJ,van de Winkel JG Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association. J Biol Chem 1995 270:29781 * PubMed

10. Patry C,Sibille Y,Lehuen A,Monteiro RC Identification of Fc alpha receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages. J Immunol 1996 156:4442 PubMed

11. Morton HC,Schiel AE,Janssen SW,van de Winkel JG Alternatively spliced forms of the human myeloid Fc alpha receptor (CD89) in neutrophils. Immunogenetics 1996 43:246 ** PubMed

12. Carayannopoulos L,Hexham JM,Capra JD Localization of the binding site for the monocyte immunoglobulin (Ig) A- Fc receptor (CD89) to the domain boundary between Calpha2 and Calpha3 in human IgA1. J Exp Med 1996 183:1579 PubMed

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* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov