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PROW: CD30
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PROW and IWHLDA present the GUIDE on:
CD30
Author: Michael Lotze
Reviewer: Toshiki Watanabe
[GUIDE BAR]

ALTERNATE NAMES FOR CD30  

MAJOR LINKS FOR CD30  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD30   - No information

CELLULAR FUNCTION OF CD30  

DISEASE RELEVANCE OF CD30 AND FUNCTION OF CD30 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD30  

MOLECULAR STRUCTURE OF CD30  

MOLECULAR MASS OF CD30  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Unspecified 120 kDa 105 kDa**  

POST-TRANSCRIPTIONAL MODIFICATION OF CD30  

POST-TRANSLATIONAL MODIFICATION OF CD30  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD30  

SUBSTRATES FOR CD30   - No information

ENZYMES WHICH MODIFY CD30  

MOLECULECOMMENT
Metalloproteinase**  

LIGANDS FOR CD30 AND MOLECULES ASSOCIATED WITH CD30  

MOLECULECOMMENT
CD153 (CD30L) Present on neutrophils, activated T-cells, macrophages and monocytes (See below)
TRAF1 See Note 1
TRAF2 See Note 1
TRAF3 See Note 1
TRAF5 See Note 1

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD30  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD30  
REAGENTS
CD30-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
NL-62    
NL-71    

SELECTION OF OTHER CD30-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
Ki-1    
Ber-H2    
M44    
M67    

 
SELECTED REFERENCES ON CD30  

REVIEWS

1. Del Prete G,Maggi E,Pizzolo G,Romagnani S CD30, Th2 cytokines and HIV infection: a complex and fascinating link. Immunol Today 1995 16:76 PubMed

2. Falini B,Pileri S,Pizzolo G,Durkop H,Flenghi L,Stirpe F,Martelli MF,Stein H CD30 (Ki-1) molecule: a new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy. Blood 1995 85:1 ** PubMed

3. de Bruin PC,Gruss HJ,van der Valk P,Willemze R,Meijer CJ CD30 expression in normal and neoplastic lymphoid tissue: biological aspects and clinical implications. Leukemia 1995 9:1620 PubMed

PRIMARY CITATIONS

4. Agrawal B,Reddish M,Longenecker BM CD30 expression on human CD8+ T cells isolated from peripheral blood lymphocytes of normal donors. J Immunol 1996 157:3229 PubMed

5. Aizawa S,Nakano H,Ishida T,Horie R,Nagai M,Ito K,Yagita H,Okumura K,Inoue J,Watanabe T Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. J Biol Chem 1997 272:2042 ** PubMed

6. Aizawa S,Satoh H,Horie R,Ito K,Choi SH,Takeuchi H,Watanabe T Cloning and characterization of a cDNA for rat CD30 homolog and chromosomal assignment of the genomic gene. Gene 1996 182:155 ** PubMed

7. Alzona M,Jack HM,Fisher RI,Ellis TM IL-12 activates IFN-gamma production through the preferential activation of CD30+ T cells. J Immunol 1995 154:9 PubMed

8. Amakawa R,Hakem A,Kundig TM,Matsuyama T,Simard JJ,Timms E,Wakeham A,Mittruecker HW,Griesser H,Takimoto H,Schmits R,Shahinian A,Ohashi P,Penninger JM,Mak TW Impaired negative selection of T cells in Hodgkin's disease antigen Cell 1996 84:551 PubMed

9. Ansieau S,Scheffrahn I,Mosialos G,Brand H,Duyster J,Kaye K,Harada J,Dougall B,Hubinger G,Kieff E,Herrmann F,Leutz A,Gruss HJ Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and Proc Natl Acad Sci U S A 1996 93:14053 ** PubMed

10. Biswas P,Smith CA,Goletti D,Hardy EC,Jackson RW,Fauci AS Cross-linking of CD30 induces HIV expression in chronically infected T cells. Immunity 1995 2:587 PubMed

11. Bowen MA,Lee RK,Miragliotta G,Nam SY,Podack ER Structure and expression of murine CD30 and its role in cytokine production. J Immunol 1996 156:442 PubMed

12. Del Prete G,De Carli M,D'Elios MM,Daniel KC,Almerigogna F,Alderson M,Smith CA,Thomas E,Romagnani S CD30-mediated signaling promotes the development of human T helper type 2-like T cells. J Exp Med 1995 182:1655 PubMed

13. Duckett CS,Gedrich RW,Gilfillan MC,Thompson CB Induction of nuclear factor kappaB by the CD30 receptor is mediated by TRAF1 and TRAF2. Mol Cell Biol 1997 17:1535 ** PubMed

14. Gedrich RW,Gilfillan MC,Duckett CS,Van Dongen JL,Thompson CB CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins. J Biol Chem 1996 271:12852 PubMed

15. Hamann D,Hilkens CM,Grogan JL,Lens SM,Kapsenberg ML,Yazdanbakhsh M,van Lier RA CD30 expression does not discriminate between human Th1- and Th2-type T cells. J Immunol 1996 156:1387 PubMed

16. Horie R,Ito K,Tatewaki M,Nagai M,Aizawa S,Higashihara M,Ishida T,Inoue J,Takizawa H,Watanabe T A variant CD30 protein lacking extracellular and transmembrane domains is induced in HL-60 by tetradecanoylphorbol acetate and is expressed in alveolar macrophages. Blood 1996 88:2422 ** PubMed

17. Lee SY,Park CG,Choi Y T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors. J Exp Med 1996 183:669 PubMed

18. Nador RG,Cesarman E,Chadburn A,Dawson DB,Ansari MQ,Sald J,Knowles DM Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus. Blood 1996 88:645 PubMed

19. Wiley SR,Goodwin RG,Smith CA Reverse signaling via CD30 ligand. J Immunol 1996 157:3635 PubMed

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Modified 10/14/99   mpr@mail.nih.gov